Human Papillomavirus 16 and 18 Infection in Oral Cancer in Thailand: A Multicenter Study.
Aged
Carcinoma, Squamous Cell
/ epidemiology
Female
Follow-Up Studies
Human papillomavirus 16
/ isolation & purification
Human papillomavirus 18
/ isolation & purification
Humans
Male
Middle Aged
Mouth Neoplasms
/ epidemiology
Papillomavirus Infections
/ complications
Prognosis
Thailand
/ epidemiology
HPV16/18
P16
Thailand
multicenter study
oral squamous cell carcinoma
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
25
07
2020
entrez:
28
11
2020
pubmed:
29
11
2020
medline:
3
8
2021
Statut:
epublish
Résumé
To identify the prevalence of high-risk human papillomavirus (HPV) genotypes 16 and 18 among patients with oral squamous cell carcinoma (OSCC) in Thailand and investigate the associations of p16 expression and HPV16/18 with the demographic, clinicopathologic, and risk parameters. A total of 403 formalin-fixed paraffin-embedded OSCC specimens from four centers in four regions were obtained. p16 expression was evaluated by immunohistochemistry. The detection of HPV16/18 DNA was performed by polymerase chain reaction. Results: Of all, 172 specimens (42.7%) were presented with amplifiable extracted DNA. Among these, 62.8% were positive for p16, 8.1% were positive for HPV16/18, and 5.8% were positive for both methods. Of all HPV-positive specimens, HPV18 was detected in 57.1%; HPV16 in 14.3%; and HPV16 and 18 (co-infection) in 28.6%. The prevalence of HPV16/18 varied between centers, with the highest rate in the northern center (20.0%). There was no significant correlation between p16 expression and HPV16/18. There were no significant associations of p16 expression and/or HPV16/18 with all variables. The prevalence of HPV16/18 infection in OSCC geographically varied in Thailand, with the highest rate in the northern region. Poor correlation between p16 and HPV16/18 suggests p16 not be used as a surrogate marker for HPV-positive OSCC.<br />.
Identifiants
pubmed: 33247695
doi: 10.31557/APJCP.2020.21.11.3349
pmc: PMC8033133
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
3349-3355Références
BMC Cancer. 2018 Mar 27;18(1):324
pubmed: 29580212
Asian Pac J Cancer Prev. 2011;12(4):853-6
pubmed: 21790214
Mod Pathol. 2012 Oct;25(10):1354-63
pubmed: 22684225
Appl Immunohistochem Mol Morphol. 2017 May/Jun;25(5):366-373
pubmed: 26657876
JAMA Otolaryngol Head Neck Surg. 2018 Jun 1;144(6):519-525
pubmed: 29801040
Oman Med J. 2015 Nov;30(6):455-60
pubmed: 26674929
Int J Oral Sci. 2009 Sep;1(3):119-25
pubmed: 20695077
Asian Pac J Cancer Prev. ;18(7):1919-1924
pubmed: 28749621
Int J Clin Oncol. 2016 Oct;21(5):819-826
pubmed: 27339270
Int J Cancer. 2017 Mar 1;140(5):1186-1198
pubmed: 27859245
Asian Pac J Cancer Prev. 2014;15(19):8351-9
pubmed: 25339028
Lancet Oncol. 2014 Nov;15(12):1319-31
pubmed: 25439690
Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75
pubmed: 15734974
J Gen Virol. 2018 Jun;99(6):783-789
pubmed: 29708483
Int J Oral Maxillofac Surg. 2004 Jan;33(1):71-4
pubmed: 14690662
Pathobiology. 2008;75(4):257-64
pubmed: 18580072
Oral Oncol. 2013 Jan;49(1):1-8
pubmed: 22841678
Hum Vaccin Immunother. 2014;10(7):2109-11
pubmed: 25424825
Int J Infect Dis. 2018 Apr;69:115-119
pubmed: 29432879
J Med Virol. 2017 Jun;89(6):1096-1101
pubmed: 27935063
Acta Otolaryngol. 2017 Oct;137(10):1121-1126
pubmed: 28669249
Int J Cancer. 2015 Apr 1;136(7):1589-99
pubmed: 25104331
Indian J Cancer. 2015 Jul-Sep;52(3):403-5
pubmed: 26905153
J Craniomaxillofac Surg. 2014 Oct;42(7):1506-14
pubmed: 24947612
Oral Dis. 2015 May;21(4):417-31
pubmed: 24962169
Eur J Cancer. 2015 Oct;51(15):2130-2143
pubmed: 26421817
J Clin Diagn Res. 2017 Jun;11(6):XC10-XC13
pubmed: 28764278
Arch Pathol Lab Med. 2018 May;142(5):559-597
pubmed: 29251996
IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt E):1-538
pubmed: 23193840
Asian Pac J Cancer Prev. 2016;17(8):4049-57
pubmed: 27644660
Cancer. 2019 Aug 15;125(16):2782-2793
pubmed: 31012957
Asian Pac J Cancer Prev. 2011;12(3):645-8
pubmed: 21627358
Oral Oncol. 2015 Dec;51(12):1057-60
pubmed: 26520047
SAGE Open Med. 2018 Mar 19;6:2050312118765604
pubmed: 29623202
Int J Cancer. 2007 Dec 1;121(11):2465-72
pubmed: 17680565
Br J Cancer. 2015 Jul 14;113(2):321-6
pubmed: 26057450
Asian Pac J Cancer Prev. 2012;13(3):885-90
pubmed: 22631666
Laryngoscope. 2012 Jul;122(7):1558-65
pubmed: 22532307
Lancet Oncol. 2015 May;16(5):e206-16
pubmed: 25943065
Med Oncol. 2017 Sep;34(9):148
pubmed: 28741068
J Oral Sci. 2015;57(4):327-34
pubmed: 26666856
Head Neck. 2019 Mar;41(3):678-685
pubmed: 30605251
Periodontol 2000. 2011 Oct;57(1):19-37
pubmed: 21781177
Clin Microbiol Rev. 2016 Apr;29(2):291-319
pubmed: 26912568
Oral Oncol. 2016 May;56:47-53
pubmed: 27086486
Int J Oral Maxillofac Surg. 2004 Jan;33(1):84-8
pubmed: 14758820
Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):771-5
pubmed: 19256774
Cancer Lett. 2012 Oct 1;323(1):88-96
pubmed: 22484467