Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo.
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
ISSN: 1432-1777
Titre abrégé: Mamm Genome
Pays: United States
ID NLM: 9100916
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
07
2020
accepted:
18
09
2020
pubmed:
29
11
2020
medline:
21
8
2021
entrez:
28
11
2020
Statut:
ppublish
Résumé
Intracellular calcium is critical in orchestrating neuronal excitability and analgesia. Carbonic anhydrase-8 (CA8) regulates intracellular calcium signaling through allosteric inhibition of neuronal inositol trisphosphate receptor 1 (ITPR1) to produce profound analgesia. Recently, we reported the "G" allele at rs6471859 represents cis-eQTL regulating alternative splicing of a 1697 bp transcript (CA8-204
Identifiants
pubmed: 33247772
doi: 10.1007/s00335-020-09848-y
pii: 10.1007/s00335-020-09848-y
doi:
Substances chimiques
Biomarkers, Tumor
0
DNA, Complementary
0
Peptides
0
Adenosine Triphosphate
8L70Q75FXE
CA8 protein, human
EC 4.2.1.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-294Subventions
Organisme : NINDS NIH HHS
ID : R21 NS105880
Pays : United States