Point-of-care measured serum cholinesterase activity predicts patient outcome following severe burns.
Adult
Aged
Body Surface Area
Burn Units
/ organization & administration
Burns
/ complications
Cholinesterases
/ analysis
Cohort Studies
Diagnostic Techniques and Procedures
/ instrumentation
Emergency Service, Hospital
/ organization & administration
Female
Hospitalization
/ statistics & numerical data
Humans
Male
Middle Aged
Outcome Assessment, Health Care
/ methods
Point-of-Care Systems
Predictive Value of Tests
Risk Assessment
/ methods
Burn injury
Butyrylcholinesterase
Inflammation
Point of care testing
Risk stratification
serum cholinesterase
Journal
Burns : journal of the International Society for Burn Injuries
ISSN: 1879-1409
Titre abrégé: Burns
Pays: Netherlands
ID NLM: 8913178
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
16
07
2020
revised:
04
10
2020
accepted:
19
10
2020
pubmed:
30
11
2020
medline:
9
11
2021
entrez:
29
11
2020
Statut:
ppublish
Résumé
Risk stratification is of utmost importance in burn therapy. However, suitable bedside biomarkers to evaluate the emerging inflammatory response following burn injuries are missing. Serum cholinesterase (butyrylcholinesterase, BChE) has been shown to be a clinically relevant biomarker in acute inflammatory diseases including burns. In this observational cohort study BChE activity was measured by using point-of-care testing (POCT), a novel method in acute burn care. POCT measurements were performed at emergency room admission (ERA) of 35 patients and repeated 12, 24 and 48 h later. All patients or their legal designees gave informed consent. Patients with burn injuries showed sustained BChE activity reduction following hospital admission. BChE activity correlated negatively with burn injury severity, organ failure severity and intensive care unit resource requirements. BChE activity measured at ERA and 12 h later identified survivors and predicted 28-day patient outcome with noninferior efficacy compared to the abbreviated burn severity index (ABSI) scoring. Finally, POCT-measured BChE activity might complement ABSI scoring and possibly improve early risk stratification in acute burn care therapy.
Identifiants
pubmed: 33248805
pii: S0305-4179(20)30576-3
doi: 10.1016/j.burns.2020.10.027
pii:
doi:
Substances chimiques
Cholinesterases
EC 3.1.1.8
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
863-872Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.