Blood cadmium levels as a marker for early lung cancer detection.

Adult Aged Aged, 80 and over Biomarkers, Tumor / blood Cadmium / blood Case-Control Studies Female Humans Lung Neoplasms / blood Male Middle Aged Risk Factors Smoking / blood

Cadmium Detection marker Lung cancer

Journal

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

ISSN: 1878-3252

Titre abrégé: J Trace Elem Med Biol

Pays: Germany

ID NLM: 9508274

Informations de publication

Date de publication:
Mar 2021

Historique:

received: 22 06 2020

revised: 16 09 2020

accepted: 06 11 2020

pubmed: 30 11 2020

medline: 29 9 2021

entrez: 29 11 2020

Statut: ppublish

Résumé

We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer. We measured blood cadmium levels among 205 lung cancer patients and 205 matched controls. Cases and controls were matched for sex, age and smoking history (total pack-years, years since cessation for former smokers). The odds ratio for those in the highest quartile of cadmium level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01-9.67, p < 0.01). The association was present in former smokers (OR = 16.8, 95 % CI:3.96-71.2, p < 0.01), but not in current smokers (OR = 1.23, 95 % CI: 0.34-4.38) or in never smokers (OR not defined). Among former smokers, the association was present in both early- and late-stage lung cancer. Blood cadmium levels may be a marker to help with the early detection of lung cancer among former smokers.

Sections du résumé

BACKGROUND BACKGROUND

We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer.

MATERIAL AND METHODS METHODS

We measured blood cadmium levels among 205 lung cancer patients and 205 matched controls. Cases and controls were matched for sex, age and smoking history (total pack-years, years since cessation for former smokers).

RESULTS RESULTS

The odds ratio for those in the highest quartile of cadmium level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01-9.67, p < 0.01). The association was present in former smokers (OR = 16.8, 95 % CI:3.96-71.2, p < 0.01), but not in current smokers (OR = 1.23, 95 % CI: 0.34-4.38) or in never smokers (OR not defined). Among former smokers, the association was present in both early- and late-stage lung cancer.

CONCLUSION CONCLUSIONS

Blood cadmium levels may be a marker to help with the early detection of lung cancer among former smokers.

Identifiants

DOI: 10.1016/j.jtemb.2020.126682 PMID: 33249371

pubmed: 33249371

pii: S0946-672X(20)30247-9

doi: 10.1016/j.jtemb.2020.126682

pii:

doi:

Substances chimiques

Biomarkers, Tumor 0

Cadmium 00BH33GNGH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

126682