A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.
AFRICAN ANCESTRY POPULATION
BMD
DXA
GENERAL POPULATION STUDIES
GENETICS
GENETICS RESEARCH
HUMAN ASSOCIATION STUDIES
META-ANALYSIS
OSTEOPOROSIS
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
24
04
2020
revised:
09
11
2020
accepted:
19
11
2020
pubmed:
30
11
2020
medline:
10
8
2021
entrez:
29
11
2020
Statut:
ppublish
Résumé
Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identified in European populations were transferable to African ancestry populations. We included nearly 5000 individuals with both genetic data and assessments of BMD. Genotype imputation was conducted using the 1000G reference panel. We assessed single-nucleotide polymorphism (SNP) associations with femoral neck and lumbar spine BMD in each cohort separately, then combined results in fixed effects (or random effects if study heterogeneity was high, I
Identifiants
pubmed: 33249669
doi: 10.1002/jbmr.4220
pmc: PMC8353846
mid: NIHMS1727442
doi:
Substances chimiques
MBL2 protein, human
0
Mannose-Binding Lectin
0
Mitochondrial Membrane Transport Proteins
0
SLC25A13 protein, human
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
469-479Subventions
Organisme : NIAMS NIH HHS
ID : P60 AR049465
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600002C
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP006266
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR041398
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : ACL HHS
ID : U01DP006266
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600003C
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG033618
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR030701
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600018C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600004C
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG023480
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR049747
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP003206
Pays : United States
Organisme : ACL HHS
ID : U01DP003206
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600001C
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR051124
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072571
Pays : United States
Informations de copyright
© 2020 American Society for Bone and Mineral Research (ASBMR).
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