Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains.
Alzheimer Disease
Amyloid beta-Peptides
/ administration & dosage
Amyloid beta-Protein Precursor
/ genetics
Amyloidosis
/ metabolism
Animals
Brain
/ metabolism
Disease Models, Animal
Hippocampus
Humans
Iatrogenic Disease
Immunohistochemistry
Mice
Mice, Transgenic
Plaque, Amyloid
/ metabolism
Presenilin-1
/ genetics
Tissue Extracts
Alzheimer’s disease
Aβ transmission
β-amyloid pathology
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
30 11 2020
30 11 2020
Historique:
received:
07
10
2020
accepted:
15
11
2020
entrez:
30
11
2020
pubmed:
1
12
2020
medline:
10
11
2021
Statut:
epublish
Résumé
In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation of pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well as after cerebral surgeries. Experimentally, intracerebral inoculation of brain homogenate extracts containing misfolded Aβ can seed Aβ deposition in transgenic mouse models of amyloidosis or in non-human primates. The transmission of cerebral Aβ is governed by the host and by the inoculated samples. It is critical to better characterize the propensities of different hosts to develop Aβ deposition after contamination by an Aβ-positive sample as well as to better assess which biological samples can transmit this lesion. Aβ precursor protein (huAPP
Identifiants
pubmed: 33250056
doi: 10.1186/s40478-020-01081-7
pii: 10.1186/s40478-020-01081-7
pmc: PMC7702698
doi:
Substances chimiques
APP protein, human
0
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
PSEN1 protein, human
0
Presenilin-1
0
Tissue Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205Investigateurs
Franck Letournel
(F)
Marie-Laure Martin-Négrier
(ML)
Maxime Faisant
(M)
Catherine Godfraind
(C)
Claude-Alain Maurage
(CA)
Vincent Deramecourt
(V)
Mathilde Duchesne
(M)
David Meyronnet
(D)
André Maues de Paula
(AM)
Valérie Rigau
(V)
Fanny Vandenbos-Burel
(F)
Charles Duyckaerts
(C)
Danielle Seilhean
(D)
Susana Boluda
(S)
Isabelle Plu
(I)
Serge Milin
(S)
Dan Christian Chiforeanu
(DC)
Annie Laquerrière
(A)
Béatrice Lannes
(B)
Références
EMBO J. 1999 Dec 1;18(23):6855-64
pubmed: 10581259
J Neurosci. 2000 Jun 1;20(11):4050-8
pubmed: 10818140
Acta Neuropathol. 2012 Jan;123(1):31-7
pubmed: 22101366
Nature. 2015 Sep 10;525(7568):247-50
pubmed: 26354483
Acta Neuropathol Commun. 2013 Nov 18;1:76
pubmed: 24252208
Science. 2006 Sep 22;313(5794):1781-4
pubmed: 16990547
Nat Neurosci. 2015 Nov;18(11):1559-61
pubmed: 26352792
Acta Neuropathol. 1986;69(3-4):322-5
pubmed: 3083640
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
J Neurosci. 2011 Oct 12;31(41):14488-95
pubmed: 21994365
Acta Neuropathol Commun. 2019 Sep 4;7(1):126
pubmed: 31481130
J Neurosci. 2000 May 15;20(10):3606-11
pubmed: 10804202
Ann Neurol. 2019 Feb;85(2):284-290
pubmed: 30597599
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10329-34
pubmed: 24982137
Acta Neuropathol. 2018 Feb;135(2):201-212
pubmed: 29209767
Neurobiol Dis. 2006 Dec;24(3):516-24
pubmed: 17029828
Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11025-30
pubmed: 22711819
Acta Neuropathol. 2018 May;135(5):671-679
pubmed: 29450646
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10323-8
pubmed: 24982139
Acta Neuropathol. 2018 May;135(5):801-803
pubmed: 29508058
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2528-33
pubmed: 21262831
Mol Psychiatry. 2012 Dec;17(12):1347-53
pubmed: 21968933