Immunometabolism of regulatory T cells in cancer.
Cancer and tumor microenvironment
Immunometabolism
Treg cells
Journal
Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
01
10
2020
revised:
19
11
2020
accepted:
19
11
2020
pubmed:
1
12
2020
medline:
25
9
2021
entrez:
30
11
2020
Statut:
ppublish
Résumé
Regulatory T (Treg) cells are known to orchestrate the regulatory mechanisms aimed at suppressing pathological auto-reactive immune responses and are thus key in ensuring the maintenance of immune homeostasis. On the other hand, the presence of Treg cells with enhanced suppressive capability in a plethora of human cancers represents a major obstacle to an effective anti-cancer immune response. A relevant research effort has thus been dedicated to comprehend Treg cell biology, leading to a continuously refining characterization of their phenotype and function and unveiling the central role of metabolism in ensuring Treg cell fitness in cancer. Here we focus on how the peculiar biochemical characteristics of the tumor microenvironment actually support Treg cell metabolic activation and favor their selective survival and proliferation. Moreover, we examine the key metabolic pathways that may become useful targets of novel treatments directed at hampering tumor resident Treg cell proficiency, thus representing the next research frontier in cancer immunotherapy.
Identifiants
pubmed: 33250195
pii: S0098-2997(20)30138-2
doi: 10.1016/j.mam.2020.100936
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100936Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.