The potential of Atorvastatin for chronic lung diseases therapy.
%, Percentage
AA, Allergic asthma
AP-1, Activator protein-1
ATO, Atorvastatin
Atorvastatin
BALF, Bronchoalveolar lavage fluid
CCL7, Chemokine ligand 7
CI, Confidence interval
COPD, Chronic obstructive pulmonary disease
CRP, C-reactive protein
CS, Cigarettes smoke
CYP3A4/5, Cytochrome Metabolic enzymes3A4/5
FPP, Farnesylpyrophosphate
G, Gram
GEF, Guanine nucleotide exchange factors
GGPP, Geranylgeranylpyrophosphate
IL, Interleukins
Inflammation
Inhale
Log P, Partition coefficient
MMPs, Matrix-metalloprotease
MVA, Mevalonic acid
NADPH, Nicotinamide adenine dinucleotide phosphate
NCSCL, Non-small cell lung cancer
NF-κB, Nuclear factor kappa
NOS, Nitric oxide synthase
NaOH, Sodium hydroxide
OATP, Organic anion transporting polypeptide
Oral
Oxidation
PEG, Polyethylene glycol
PPE, Porcine pancreatic elastase
ROS, Reactive oxygen species
Respiratory diseases
SAS, Supercritical antisolvent
SphK1, Sphingosine kinase 1
TGF, Transforming growth factor
TNF-a, Tumour necrosis factor alpha
TSC, Tuberous sclerosis
UDP, Uridine diphosphate
UV, Ultraviolet light
VEGF, Vascular endothelial cell growth factor
VLDL, Very low-density lipoproteins
WHO, World Health Organization
log D, Coefficient values octanol/water
m2, Square meter
mg, Milligram
mg/day, Milligram per day
ml, Millilitres
pH, Measure of the acidity or basicity of an aqueous solution
pKa, Dissociation constant
s, Second
v/v, Volume per volume
°C/min, Temperature in degrees per minutes
μM, Micromolar
μg, Microgram
μg/day, Microgram per day
μg/mL, Microgram per millilitre
Journal
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
25
02
2020
accepted:
31
08
2020
entrez:
30
11
2020
pubmed:
1
12
2020
medline:
1
12
2020
Statut:
ppublish
Résumé
Atorvastatin (ATO) is of the statin class and is used as an orally administered lipid-lowering drug. ATO is a reversible synthetic competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase thus leading to a reduction in cholesterol synthesis. It has recently been demonstrated that ATO has different pharmacological actions, which are unrelated to its lipid-lowering effects and has the ability to treat chronic airway diseases. This paper reviews the potential of ATO as an anti-inflammatory, antioxidant, and anti-proliferative agent after oral or inhaled administration. This paper discusses the advantages and disadvantages of using ATO under conditions associated with those found in the airways. This treatment could potentially be used to support the formulating of ATO as an inhaler for the treatment of chronic respiratory diseases.
Identifiants
pubmed: 33250642
doi: 10.1016/j.jsps.2020.08.025
pii: S1319-0164(20)30205-X
pmc: PMC7679442
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1353-1363Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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