An Extremely Rare Presentation of an Alpha-Fetoprotein-Producing Esophageal Adenocarcinoma.
Alpha-fetoprotein
Esophageal cancer
Gastroesophageal reflux disease
Hepatocellular cancer
Journal
Case reports in gastroenterology
ISSN: 1662-0631
Titre abrégé: Case Rep Gastroenterol
Pays: Switzerland
ID NLM: 101474819
Informations de publication
Date de publication:
Historique:
received:
07
05
2020
accepted:
16
06
2020
entrez:
30
11
2020
pubmed:
1
12
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Alpha-fetoprotein (AFP)-producing esophageal adenocarcinoma (EAC) is an extremely rare occurrence with very few cases reported in the literature. We report the case of a 76-year-old female who presented with progressive weakness, fatigue, and a decrease in appetite for weeks and who was found to have an AFP-producing EAC with an extraordinarily high AFP level of 46,135 ng/mL. CT angiography revealed abnormal thickening of the esophagus and multiple metastatic masses throughout the liver. Upper endoscopy revealed a large mass in the distal esophagus with extension into the stomach. Biopsy confirmed the EAC. Most cases are unsuccessfully treated with surgery and chemotherapy. Serial measurement of serum AFP may be useful for monitoring clinical status and treatment response.
Identifiants
pubmed: 33250688
doi: 10.1159/000509503
pii: crg-0014-0497
pmc: PMC7670355
doi:
Types de publication
Case Reports
Langues
eng
Pagination
497-503Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
J Gastrointest Cancer. 2019 Sep;50(3):617-620
pubmed: 29457212
Scand J Gastroenterol. 1979;14(3):361-5
pubmed: 87007
Clin J Gastroenterol. 2017 Feb;10(1):7-12
pubmed: 27995468
Oncol Lett. 2016 Jul;12(1):597-600
pubmed: 27347186
Gastrointest Cancer Res. 2007 Sep;1(5):188-96
pubmed: 19262708
Pathol Res Pract. 2019 Sep;215(9):152525
pubmed: 31301878
Kaohsiung J Med Sci. 2013 Feb;29(2):106-10
pubmed: 23347813
BMJ. 2019 Jul 9;366:l4373
pubmed: 31289038
Gastroenterol Rep (Oxf). 2015 Jun 20;5(1):67-71
pubmed: 26094198
Z Gastroenterol. 2016 Oct;54(10):1147-1150
pubmed: 27723906
Hum Pathol. 2012 Nov;43(11):1799-807
pubmed: 22748473
Surg Today. 2001;31(10):915-9
pubmed: 11759890
Anticancer Res. 2003 Sep-Oct;23(5A):3837-40
pubmed: 14666685
Anticancer Res. 2005 Jul-Aug;25(4):2965-8
pubmed: 16080552
Anticancer Drugs. 2009 Jan;20(1):75-8
pubmed: 19343004
Intern Med. 2018 Aug 15;57(16):2333-2339
pubmed: 29607947