Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in
High-fat diet
apolipoprotein E knockout
brain-derived neurotropic factor
cardioprotection
exercise
low-fat diet
regulator of calcineurin 1
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
entrez:
30
11
2020
pubmed:
1
12
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene ( We examined the neuronal and cardiac protective roles of RCAN1 in ApoE-/- mice that were fed a high- or low-fat diet with and without voluntary movement for 3 months. Organ weights, laboratory data, histology, RNA expression, and behavior were examined. A high-fat diet with exercise improved depressive function, as examined by the forced swimming test, and The combination of a high-fat diet and exercise might reduce depressive function, whereas a low-fat diet with exercise leads to cardioprotection. Induction of
Identifiants
pubmed: 33251902
doi: 10.1177/0300060520964016
pmc: PMC7708711
doi:
Substances chimiques
Calcium-Binding Proteins
0
DSCR1 protein, mouse
0
Muscle Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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