Applying the Multiphase Optimization Strategy for the Development of Optimized Interventions in Palliative Care.
Multiphase Optimization Strategy
clinical trials
factorial experiment
intervention development
Journal
Journal of pain and symptom management
ISSN: 1873-6513
Titre abrégé: J Pain Symptom Manage
Pays: United States
ID NLM: 8605836
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
28
09
2020
revised:
09
11
2020
accepted:
17
11
2020
pubmed:
1
12
2020
medline:
7
8
2021
entrez:
30
11
2020
Statut:
ppublish
Résumé
Recent systematic reviews and meta-analyses have reported positive benefit of multicomponent "bundled" palliative care interventions for patients and family caregivers while highlighting limitations in determining key elements and mechanisms of improvement. Traditional research approaches, such as the randomized controlled trial (RCT), typically treat interventions as "bundled" treatment packages, making it difficult to assess definitively which aspects of an intervention can be reduced or replaced or whether there are synergistic or antagonistic interactions between intervention components. Progressing toward palliative care interventions that are effective, efficient, and scalable will require new strategies and novel approaches. One such approach is the Multiphase Optimization Strategy (MOST), a framework informed by engineering principles, that uses a systematic process to empirically identify an intervention comprised of components that positively contribute to desired outcomes under real-life constraints. This article provides a brief overview and application of MOST and factorial trial design in palliative care research, including our insights from conducting a pilot factorial trial of an early palliative care intervention to enhance the decision support skills of advanced cancer family caregivers (Project CASCADE).
Identifiants
pubmed: 33253787
pii: S0885-3924(20)30886-1
doi: 10.1016/j.jpainsymman.2020.11.017
pmc: PMC8274323
mid: NIHMS1720386
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
174-182Subventions
Organisme : NCI NIH HHS
ID : R01 CA225629
Pays : United States
Organisme : NINR NIH HHS
ID : R00 NR015903
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG044281
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA234225
Pays : United States
Organisme : AHRQ HHS
ID : T32 HS013852
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG054415
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA252868
Pays : United States
Informations de copyright
Copyright © 2020 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
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