Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment.
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
02
11
2020
revised:
20
11
2020
accepted:
22
11
2020
pubmed:
1
12
2020
medline:
15
12
2021
entrez:
30
11
2020
Statut:
ppublish
Résumé
The TP53 gene has been widely studied for its roles in cell cycle control, maintaining genome stability, activating repair mechanisms upon DNA damage, and initiating apoptosis should repair mechanisms fail. Thus, it is not surprising that mutations of p53 are the most common genetic alterations found in human cancer. Emerging evidence indicates that dysregulation of lipid metabolism by p53 can have a profound impact not only on cancer cells but also cells of the tumor microenvironment (TME). In particular, intermediates of the sphingolipid and lysophospholipid pathways regulate many cellular responses common to p53 such as cell survival, migration, DNA damage repair and apoptosis. The majority of these cellular events become dysregulated in cancer as well as cell senescence. In this review, we will provide an account on the seminal contributions of Prof. Lina Obeid, who deciphered the crosstalk between p53 and the sphingolipid pathway particularly in modulating DNA damage repair and apoptosis in non-transformed as well as transformed cells. We will also provide insights on the integrative role of p53 with the lysophosphatidic acid (LPA) signaling pathway in cancer progression and TME regulation.
Identifiants
pubmed: 33253914
pii: S0898-6568(20)30327-2
doi: 10.1016/j.cellsig.2020.109850
pmc: PMC7967251
mid: NIHMS1671784
pii:
doi:
Substances chimiques
Lysophospholipids
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
lysophosphatidic acid
PG6M3969SG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109850Subventions
Organisme : NCI NIH HHS
ID : R01 CA092160
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI107331
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI150574
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Cell Cycle. 2013 Aug 1;12(15):2479-92
pubmed: 23839035
J Mol Cell Biol. 2019 Jul 19;11(7):524-530
pubmed: 30925588
Oncogene. 2012 Mar 1;31(9):1166-75
pubmed: 21765468
Mol Cancer Res. 2010 Mar;8(3):309-21
pubmed: 20197381
Cell Death Differ. 2018 May;25(5):841-856
pubmed: 29229990
J Inflamm (Lond). 2014 Aug 09;11:23
pubmed: 25152696
J Biol Chem. 2004 May 7;279(19):20546-54
pubmed: 14988393
Front Oncol. 2014 Oct 21;4:285
pubmed: 25374842
Cell. 2005 Dec 16;123(6):1001-11
pubmed: 16360031
Mol Cancer Res. 2011 Nov;9(11):1562-70
pubmed: 21890597
Biochim Biophys Acta. 1999 Jul 9;1439(1):1-16
pubmed: 10395961
N Engl J Med. 2007 Dec 20;357(25):2543-51
pubmed: 18094375
FEBS Lett. 2006 Nov 13;580(26):6047-54
pubmed: 17064696
J Biol Chem. 2013 Aug 30;288(35):25244-25253
pubmed: 23880760
Cell. 1995 Aug 11;82(3):405-14
pubmed: 7634330
Cell Death Differ. 2004 Aug;11(8):853-61
pubmed: 15088070
J Biol Chem. 2013 May 3;288(18):12880-90
pubmed: 23519469
Sci Rep. 2015 Sep 08;5:13834
pubmed: 26346319
Biochim Biophys Acta. 2002 Dec 30;1585(2-3):108-13
pubmed: 12531543
Mol Pharmacol. 2000 Dec;58(6):1188-96
pubmed: 11093753
Rejuvenation Res. 2008 Aug;11(4):781-92
pubmed: 18729810
Apoptosis. 2020 Feb;25(1-2):135-150
pubmed: 31867678
Oncotarget. 2015 Aug 28;6(25):21240-54
pubmed: 26061814
Mol Cancer Res. 2015 Jan;13(1):174-85
pubmed: 25158955
Cell. 1979 May;17(1):43-52
pubmed: 222475
J Biol Chem. 2001 Jul 20;276(29):27129-35
pubmed: 11369765
Adv Biol Regul. 2019 Jan;71:183-193
pubmed: 30243984
Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):130-8
pubmed: 20331961
Bioessays. 2010 May;32(5):392-400
pubmed: 20414897
Cell Signal. 2020 May;69:109551
pubmed: 32006610
Mol Cancer Res. 2007 Nov;5(11):1201-11
pubmed: 18025263
Proc Natl Acad Sci U S A. 1979 May;76(5):2420-4
pubmed: 221923
Biochim Biophys Acta. 2009 May;1793(5):836-46
pubmed: 19233232
Biochim Biophys Acta. 2015 Dec;1851(12):1566-76
pubmed: 26417903
Cell Death Dis. 2015 Oct 29;6:e1947
pubmed: 26512957
J Med Chem. 2017 Feb 23;60(4):1309-1324
pubmed: 28112925
Aging Cell. 2020 Jan;19(1):e13064
pubmed: 31714004
Oncogene. 2013 Oct 24;32(43):5129-43
pubmed: 23416979
Nat Rev Mol Cell Biol. 2019 Apr;20(4):199-210
pubmed: 30824861
Mol Cell. 2012 Sep 14;47(5):681-93
pubmed: 22854598
Nature. 1979 Mar 15;278(5701):261-3
pubmed: 218111
Genes Dev. 1999 Mar 1;13(5):607-19
pubmed: 10072388
Cancer Res. 2010 Dec 1;70(23):9650-8
pubmed: 20952507
Oncogene. 2009 Feb 12;28(6):933-6
pubmed: 19060923
Adv Biol Regul. 2014 Jan;54:121-9
pubmed: 24070975
J Lipid Res. 2014 Jul;55(7):1192-214
pubmed: 24643338
Cell Rep. 2014 Jan 30;6(2):271-7
pubmed: 24412360
EMBO J. 1996 May 15;15(10):2417-24
pubmed: 8665849
J Proteome Res. 2009 Oct;8(10):4810-22
pubmed: 19705920
Sci Rep. 2017 Mar 15;7:44573
pubmed: 28294157
Biochem Soc Trans. 2005 Dec;33(Pt 6):1370-4
pubmed: 16246121
Adv Exp Med Biol. 2010;688:1-23
pubmed: 20919643
Mol Cancer Res. 2008 Sep;6(9):1452-60
pubmed: 18723828
J Biol Chem. 1995 Feb 3;270(5):2047-52
pubmed: 7836432
Cell. 2008 May 30;133(5):864-77
pubmed: 18510930
PLoS One. 2012;7(2):e32185
pubmed: 22359668
Mech Ageing Dev. 2006 May;127(5):481-9
pubmed: 16516270
Cell Signal. 2015 Sep;27(9):1751-62
pubmed: 26027517
Acta Diabetol. 2013 Jun;50(3):363-71
pubmed: 22864860
Cell. 2017 Sep 7;170(6):1062-1078
pubmed: 28886379
Int J Mol Sci. 2020 Aug 18;21(16):
pubmed: 32824846
Eur J Neurosci. 2001 Jun;13(11):2037-46
pubmed: 11422444
Nature. 1995 Oct 19;377(6550):646-9
pubmed: 7566179
Anim Reprod Sci. 2018 May;192:242-250
pubmed: 29573844
Cell. 1996 Jul 26;86(2):189-99
pubmed: 8706124
Oncotarget. 2016 Apr 5;7(14):18440-57
pubmed: 26943039
FEBS Open Bio. 2017 Dec 08;8(1):27-40
pubmed: 29321954
Oncogene. 2006 Nov 23;25(55):7305-10
pubmed: 16785993
Cell Signal. 2010 Jun;22(6):926-35
pubmed: 20100569
Mediators Inflamm. 2017;2017:9173090
pubmed: 29430083
Cancer Res. 2018 Jul 1;78(13):3634-3644
pubmed: 29724718
Biomed Res Int. 2015;2015:598386
pubmed: 26366416
Biochem J. 1998 Nov 1;335 ( Pt 3):465-80
pubmed: 9794783
J Clin Invest. 1998 Jul 15;102(2):329-39
pubmed: 9664074
Biochim Biophys Acta. 2014 May;1841(5):671-81
pubmed: 24021978
J Biol Chem. 1998 Apr 3;273(14):7906-10
pubmed: 9525886
Sci Rep. 2019 Mar 26;9(1):5195
pubmed: 30914657
Cell. 2013 Apr 11;153(2):449-60
pubmed: 23562644
Br J Pharmacol. 2014 Aug;171(15):3575-94
pubmed: 24602016
Science. 1993 Mar 19;259(5102):1769-71
pubmed: 8456305
J Biol Chem. 1998 Feb 13;273(7):4096-105
pubmed: 9461603
Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):41-8
pubmed: 18400537
Nature. 2013 Oct 17;502(7471):333-339
pubmed: 24132290
Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191
pubmed: 29165427
Am J Respir Cell Mol Biol. 2012 Mar;46(3):355-64
pubmed: 22021336
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17384-9
pubmed: 17090686
Nat Commun. 2018 Oct 8;9(1):4149
pubmed: 30297838
J Exp Med. 1994 Aug 1;180(2):525-35
pubmed: 8046331
Oncogene. 2018 May;37(18):2379-2393
pubmed: 29429991
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):109-14
pubmed: 10618379
Cancer Discov. 2019 May;9(5):617-627
pubmed: 30837243
Apoptosis. 2015 Mar;20(3):273-84
pubmed: 25633408
Blood. 2014 Nov 13;124(20):3141-50
pubmed: 25277122
Oncogene. 2001 Mar 15;20(11):1368-78
pubmed: 11313880
Cancer Res. 2011 Nov 15;71(22):7038-47
pubmed: 22006999
FEBS Lett. 2012 Oct 19;586(20):3681-91
pubmed: 22975311
Oncogene. 2003 Nov 27;22(54):8645-52
pubmed: 14647458
Annu Rev Pharmacol Toxicol. 2010;50:157-86
pubmed: 20055701
Biochem Biophys Res Commun. 1997 Jul 9;236(1):106-12
pubmed: 9223435
Semin Cell Dev Biol. 2010 Feb;21(1):47-54
pubmed: 19914385
Adv Biol Regul. 2015 May;58:38-52
pubmed: 25434743
Int J Mol Sci. 2019 Sep 02;20(17):
pubmed: 31480728
J Pathol. 2014 Oct;234(2):190-202
pubmed: 24852265
Biochem J. 2015 Aug 1;469(3):325-46
pubmed: 26205489