Antibacterial and Anti-Inflammatory Activity of an Antimicrobial Peptide Synthesized with D Amino Acids.

anti-inflammatory activity antibacterial agents antimicrobial peptides

Journal

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404

Informations de publication

Date de publication:
24 Nov 2020
Historique:
received: 21 10 2020
revised: 17 11 2020
accepted: 22 11 2020
entrez: 1 12 2020
pubmed: 2 12 2020
medline: 2 12 2020
Statut: epublish

Résumé

The peptide SET-M33 is a molecule synthesized in tetra-branched form which is being developed as a new antibiotic against Gram-negative bacteria. Its isomeric form with D amino acids instead of the L version (SET-M33D) is also able to kill Gram-positive bacteria because of its higher resistance to bacterial proteases (Falciani et al.,

Identifiants

pubmed: 33255172
pii: antibiotics9120840
doi: 10.3390/antibiotics9120840
pmc: PMC7760307
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Jlenia Brunetti (J)

Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.

Veronica Carnicelli (V)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Alessia Ponzi (A)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Antonio Di Giulio (A)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Anna Rita Lizzi (AR)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Loredana Cristiano (L)

Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Laura Cresti (L)

SetLance srl, Toscana Life Sciences, 53100 Siena, Italy.

Giovanni Cappello (G)

Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.

Simona Pollini (S)

Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Microbiology and Virology Unit, Careggi University Hospital, 50134 Florence, Italy.

Lara Mosconi (L)

Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

Gian Maria Rossolini (GM)

Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Microbiology and Virology Unit, Careggi University Hospital, 50134 Florence, Italy.

Luisa Bracci (L)

Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Laboratory of Clinical Pathology, Santa Maria alle Scotte Hospital, 53100 Siena, Italy.

Chiara Falciani (C)

Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.

Alessandro Pini (A)

Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Laboratory of Clinical Pathology, Santa Maria alle Scotte Hospital, 53100 Siena, Italy.

Classifications MeSH