Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome.

3-[18F]fluoro-5-(2-pyridinylethynyl)benzonitrile ([18F]FPEB) FMR1 gene Fragile X Mental Retardation Protein (FMRP) binding potential caudate nucleus genetic mutation magnetic resonance imaging (MRI) mosaicism neuropsychological testing positron emission tomography (PET)

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
24 Nov 2020
Historique:
received: 30 08 2020
revised: 07 11 2020
accepted: 14 11 2020
entrez: 1 12 2020
pubmed: 2 12 2020
medline: 2 12 2020
Statut: epublish

Résumé

Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR

Identifiants

pubmed: 33255214
pii: brainsci10120899
doi: 10.3390/brainsci10120899
pmc: PMC7760509
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD103538
Pays : United States
Organisme : The Russell H. Morgan Department of Radiology and Radiological Science of The Johns Hopkins University
ID : 80046104
Organisme : NCATS NIH HHS
ID : UL1 TR003098
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD079123
Pays : United States

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Auteurs

James R Brašić (JR)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Ayon Nandi (A)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

David S Russell (DS)

Clinical Research, Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
Research Clinic, Invicro LLC, New Haven, CT 06510, USA.

Danna Jennings (D)

Clinical Research, Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
Research Clinic, Invicro LLC, New Haven, CT 06510, USA.
Denali Therapeutics, Inc., South San Francisco, CA 94080, USA.

Olivier Barret (O)

Clinical Research, Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.

Anil Mathur (A)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Keith Slifer (K)

Department of Psychiatry and Behavioral Sciences-Child Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD 21205, USA.

Thomas Sedlak (T)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Psychiatry and Behavioral Sciences-General Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Samuel D Martin (SD)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Neuroscience, Zanvyl Krieger School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

Zabecca Brinson (Z)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Pankhuri Vyas (P)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

John P Seibyl (JP)

Clinical Research, Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
Research Clinic, Invicro LLC, New Haven, CT 06510, USA.

Elizabeth M Berry-Kravis (EM)

Departments of Pediatrics, Neurological Sciences, and Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.

Dean F Wong (DF)

Section of High Resolution Brain Positron Emission Tomography Imaging, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Precision Radio-Theranostics Translational Laboratories, Mallinckrodt Institute of Radiology, School of Medicine, Washington University, Saint Louis, MO 63110, USA.

Dejan B Budimirovic (DB)

Department of Psychiatry and Behavioral Sciences-Child Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Departments of Psychiatry and Neurogenetics, Kennedy Krieger Institute, Baltimore, MD 21205, USA.

Classifications MeSH