Epigenetic Patterns in Five-Year-Old Children Exposed to a Low Glycemic Index Dietary Intervention during Pregnancy: Results from the ROLO Kids Study.
childhood
epigenetics
fetal programming
nutrition
pregnancy
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
24 Nov 2020
24 Nov 2020
Historique:
received:
28
09
2020
revised:
17
11
2020
accepted:
20
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
23
4
2021
Statut:
epublish
Résumé
A range of in utero and early-life factors can influence offspring epigenetics, particularly DNA methylation patterns. This study aimed to investigate the influence of a dietary intervention and factors in pregnancy on offspring epigenetic profile at five years of age. We also explored associations between body composition and methylation profile in a cross-sectional analysis. Sixty-three five-year-olds were selected from the ROLO Kids Study, a Randomized controlled trial Of a LOw glycemic index dietary intervention from the second trimester of pregnancy. DNA methylation was investigated in 780,501 CpG sites in DNA isolated from saliva. Principal component analysis identified no association between maternal age, weight, or body mass index (BMI) during pregnancy and offspring DNA methylation (
Identifiants
pubmed: 33255249
pii: nu12123602
doi: 10.3390/nu12123602
pmc: PMC7760894
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union's Seventh Framework Programme project EarlyNutrition
ID : FP7/2007-2013, grant agreement no. 289346
Organisme : The National Maternity Hospital Medical Fund
ID : -
Organisme : Health Research Board Ireland
ID : Health Research Centre for Health and Diet Research
Organisme : National Health and Medical Research Council (Australia) Senior Research Fellowship
ID : -
Références
Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):90-3
pubmed: 18226060
Prog Biophys Mol Biol. 2015 Jul;118(1-2):55-68
pubmed: 25792090
Int J Epidemiol. 2015 Aug;44(4):1288-304
pubmed: 25855720
J Exp Biol. 2015 Jan 1;218(Pt 1):71-9
pubmed: 25568453
Diabetes. 2011 May;60(5):1528-34
pubmed: 21471513
PLoS Med. 2017 Jan 24;14(1):e1002221
pubmed: 28118352
Hum Mol Genet. 2015 Jul 1;24(13):3752-63
pubmed: 25869828
BMJ. 2012 Aug 30;345:e5605
pubmed: 22936795
Reproduction. 2014 Dec;148(6):R111-20
pubmed: 25187623
JCI Insight. 2018 Sep 6;3(17):
pubmed: 30185669
Acta Physiol (Oxf). 2011 Jun;202(2):103-18
pubmed: 21401888
Cell Physiol Biochem. 2016;39(3):919-38
pubmed: 27513464
PLoS One. 2012;7(3):e31821
pubmed: 22431966
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Epigenomics. 2016 Nov;8(11):1495-1505
pubmed: 27762626
Int J Epidemiol. 2015 Aug;44(4):1211-23
pubmed: 25944819
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Br J Nutr. 2011 Apr;105(8):1117-32
pubmed: 21144094
Int J Epidemiol. 2007 Dec;36(6):1196-204
pubmed: 17591638
Am J Clin Nutr. 2016 Apr;103(4):1073-82
pubmed: 26936333
PLoS One. 2013 May 31;8(5):e64887
pubmed: 23741411
Nutrients. 2014 Jun 02;6(6):2165-78
pubmed: 24892374
Arch Dis Child. 1995 Jul;73(1):25-9
pubmed: 7639544
PLoS One. 2012;7(5):e37933
pubmed: 22666415
BMJ. 1995 Jul 15;311(6998):171-4
pubmed: 7613432
Dev Psychopathol. 2012 Nov;24(4):1377-90
pubmed: 23062304
Nat Cell Biol. 2011 Sep 02;13(9):1016-23
pubmed: 21892142
BMC Med. 2017 Mar 7;15(1):50
pubmed: 28264723
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Nutrients. 2015 Nov 17;7(11):9492-507
pubmed: 26593940
PLoS One. 2016 May 12;11(5):e0155554
pubmed: 27171005
Epigenetics. 2014 Mar;9(3):338-45
pubmed: 24316753
Nat Rev Genet. 2008 Jan;9(1):49-61
pubmed: 18071321
Lancet. 2014 Jun 7;383(9933):1990-8
pubmed: 24630777
J Pediatr. 2011 Jun;158(6):941-6
pubmed: 21238981
Lancet. 2017 Dec 16;390(10113):2627-2642
pubmed: 29029897
Genome Biol. 2012 Jun 15;13(6):R44
pubmed: 22703947
Nutrients. 2018 Apr 06;10(4):
pubmed: 29642382
Adv Genet. 2010;71:3-39
pubmed: 20933124
BMC Pediatr. 2015 Nov 10;15:175
pubmed: 26555879