Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy.
Hypolipidemia
atherosclerosis
endothelial function
flow-mediated vasodilation
low-density cholesterol
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Nov 2020
24 Nov 2020
Historique:
received:
21
10
2020
revised:
10
11
2020
accepted:
21
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
2
12
2020
Statut:
epublish
Résumé
An elevation of serum low-density lipoprotein cholesterol (LDL-C) levels has been associated with endothelial dysfunction in statin naïve subjects. However, there is no information on endothelial function in subjects with extremely low levels of LDL-C. The purpose of the present study was to determine the relationship of LDL-C levels, especially low levels of LDL-C, with endothelial function. Endothelial function assessed by flow-mediated vasodilation (FMD) measurement and LDL-C levels were evaluated in 7120 subjects without lipid-lowering therapy. We divided the subjects into five groups by LDL-C levels: <70 mg/dL, 70-99 mg/dL, 100-119 md/dL, 120-139 mg/dL, and ≥140 mg/dL. FMD values were significantly smaller in subjects with LDL-C levels of ≥140 mg/dL than in those with LDL-C levels of 70-99 mg/dL and 100-119 mg/dL (
Identifiants
pubmed: 33255270
pii: jcm9123796
doi: 10.3390/jcm9123796
pmc: PMC7761134
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan
ID : 18590815 and 21590898 to Y.H.
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