Induced Pluripotency: A Powerful Tool for In Vitro Modeling.
cell reprogramming
disease modeling
in vitro biomedical models
induced pluripotent stem cells
neural precursor cells
neurodegenerative disease
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Nov 2020
24 Nov 2020
Historique:
received:
25
10
2020
revised:
13
11
2020
accepted:
17
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
6
3
2021
Statut:
epublish
Résumé
One of the greatest breakthroughs of regenerative medicine in this century was the discovery of induced pluripotent stem cell (iPSC) technology in 2006 by Shinya Yamanaka. iPSCs originate from terminally differentiated somatic cells that have newly acquired the developmental capacity of self-renewal and differentiation into any cells of three germ layers. Before iPSCs can be used routinely in clinical practice, their efficacy and safety need to be rigorously tested; however, iPSCs have already become effective and fully-fledged tools for application under in vitro conditions. They are currently routinely used for disease modeling, preparation of difficult-to-access cell lines, monitoring of cellular mechanisms in micro- or macroscopic scales, drug testing and screening, genetic engineering, and many other applications. This review is a brief summary of the reprogramming process and subsequent differentiation and culture of reprogrammed cells into neural precursor cells (NPCs) in two-dimensional (2D) and three-dimensional (3D) conditions. NPCs can be used as biomedical models for neurodegenerative diseases (NDs), which are currently considered to be one of the major health problems in the human population.
Identifiants
pubmed: 33255453
pii: ijms21238910
doi: 10.3390/ijms21238910
pmc: PMC7727808
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Research and Development Support Agency (APVV-17-0037), Slovak Scientific Grant Agency (VEGA 1/0279/18) and GUK 366/2020 from the Ministry of Education of the Slovak Republic.
ID : VEGA 1/0279/18 and APVV-17-0037 and GUK 366/2020
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