Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma.
DLC1
HCC
MRTF
SRF
senescence
senolytics
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 11 2020
25 11 2020
Historique:
received:
03
10
2020
revised:
17
11
2020
accepted:
20
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
23
6
2021
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivators, Myocardin-Related Transcription Factors A and B (MRTF-A and -B), in HCC formation and progression has received considerable attention. Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. In this article, we describe the key features and the functional role of senescence in light of the development of novel drug targets for HCC therapy with a focus on MRTFs.
Identifiants
pubmed: 33255630
pii: cells9122540
doi: 10.3390/cells9122540
pmc: PMC7761055
pii:
doi:
Substances chimiques
Serum Response Factor
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Am J Physiol Renal Physiol. 2008 May;294(5):F1116-28
pubmed: 18337547
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13742-7
pubmed: 8943005
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L391-401
pubmed: 21224216
Aging Cell. 2017 Jun;16(3):564-574
pubmed: 28371119
Oncogene. 2012 Aug 30;31(35):3913-23
pubmed: 22139079
N Engl J Med. 2008 Jul 24;359(4):378-90
pubmed: 18650514
Science. 2001 Feb 2;291(5505):868-71
pubmed: 11157165
Exp Gerontol. 2015 Aug;68:19-25
pubmed: 25446976
Science. 2001 Feb 2;291(5505):872-5
pubmed: 11157166
Postgrad Med J. 2000 Jan;76(891):4-11
pubmed: 10622772
Nat Cell Biol. 2015 Aug;17(8):1049-61
pubmed: 26147250
Nat Rev Cancer. 2015 Jul;15(7):397-408
pubmed: 26105537
J Hematol Oncol. 2018 Feb 26;11(1):28
pubmed: 29482578
Int J Oncol. 2007 Dec;31(6):1309-15
pubmed: 17982656
Nat Cell Biol. 2017 Dec;19(12):1389-1399
pubmed: 29131140
Nat Cell Biol. 2015 Oct;17(10):1370
pubmed: 26419804
Br J Pharmacol. 2012 Jun;166(4):1357-76
pubmed: 22242975
Development. 2017 Jan 1;144(1):106-114
pubmed: 27888193
Cancer Res. 2020 May 15;80(10):1927-1941
pubmed: 32179513
Cancer Metastasis Rev. 2009 Jun;28(1-2):77-83
pubmed: 19221866
JCI Insight. 2016 Aug 4;1(12):e87732
pubmed: 27699227
Eur Respir J. 2017 Aug 3;50(2):
pubmed: 28775044
Biochem Pharmacol. 2002 Sep;64(5-6):1007-9
pubmed: 12213599
Semin Immunol. 2012 Oct;24(5):309-20
pubmed: 22559987
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):844-9
pubmed: 20080763
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Biochem Pharmacol. 2015 Aug 15;96(4):337-48
pubmed: 26093063
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Exp Gerontol. 2000 Oct;35(8):927-45
pubmed: 11121681
Cell. 1997 Mar 7;88(5):593-602
pubmed: 9054499
Cancer Discov. 2016 Apr;6(4):353-67
pubmed: 26658964
Genes Dev. 2004 Aug 1;18(15):1781-99
pubmed: 15289453
Nucleus. 2016 Apr 25;7(2):121-5
pubmed: 27104924
Nat Commun. 2020 Apr 22;11(1):1935
pubmed: 32321921
Cancer Res. 2013 Sep 1;73(17):5438-48
pubmed: 23864327
Nature. 2011 Nov 09;479(7374):547-51
pubmed: 22080947
Nature. 2005 Aug 4;436(7051):720-4
pubmed: 16079850
Sci Signal. 2015 Nov 10;8(402):ra112
pubmed: 26554816
FASEB J. 2002 Jul;16(9):935-42
pubmed: 12087054
FASEB J. 2010 Apr;24(4):1284-95
pubmed: 20008164
Nat Commun. 2017 Sep 4;8(1):422
pubmed: 28871086
Age (Dordr). 2009 Mar;31(1):1-9
pubmed: 19234764
Nat Rev Cancer. 2006 Sep;6(9):674-87
pubmed: 16929323
Cell Rep. 2017 Apr 18;19(3):584-600
pubmed: 28423321
Nat Med. 2012 Mar 04;18(4):529-37
pubmed: 22388088
Nat Cell Biol. 2020 Jun;22(6):728-739
pubmed: 32367049
Genes Dev. 2008 Jun 1;22(11):1439-44
pubmed: 18519636
Cell. 2014 Jan 30;156(3):563-76
pubmed: 24440334
Cell. 2005 Feb 25;120(4):513-22
pubmed: 15734683
J Pathol. 2008 Jan;214(2):199-210
pubmed: 18161745
Cancer Cell. 2016 Oct 10;30(4):533-547
pubmed: 27728804
Trends Cell Biol. 2018 Sep;28(9):723-737
pubmed: 29776716
Nature. 2018 Jan 4;553(7686):96-100
pubmed: 29258294
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):454-463
pubmed: 31871210
Cell. 2008 Aug 22;134(4):657-67
pubmed: 18724938
Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G504-G517
pubmed: 31928221
Gastroenterology. 2004 Nov;127(5 Suppl 1):S35-50
pubmed: 15508101
Cell Mol Life Sci. 2019 Mar;76(6):1169-1183
pubmed: 30599068
Mutat Res. 1991 Mar-Nov;256(2-6):271-82
pubmed: 1722017
Biogerontology. 2013 Dec;14(6):609-15
pubmed: 23929205
Nat Cell Biol. 2010 Jul;12(7):676-85
pubmed: 20526329
Cancer Res. 2013 Jan 1;73(1):450-8
pubmed: 23288917
Biogerontology. 2019 Jun;20(3):331-335
pubmed: 30798505
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
pubmed: 21296855
Biogerontology. 2013 Dec;14(6):617-28
pubmed: 24114507
Nat Rev Cancer. 2014 Aug;14(8):547-58
pubmed: 25030953
EMBO J. 2015 Jun 3;34(11):1493-508
pubmed: 25736378
Oncogene. 2003 May 19;22(20):3063-9
pubmed: 12789281
Am J Respir Crit Care Med. 2014 May 15;189(10):1161-72
pubmed: 24641682
Aging (Albany NY). 2013 Sep;5(9):639-40
pubmed: 24057649
Nature. 2014 May 22;509(7501):439-46
pubmed: 24848057
Aging Cell. 2015 Aug;14(4):644-58
pubmed: 25754370
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
Nat Rev Drug Discov. 2017 Oct;16(10):718-735
pubmed: 28729727
Nature. 1998 Jun 25;393(6687):809-12
pubmed: 9655398
Rev Epidemiol Sante Publique. 2014 Apr;62(2):95-108
pubmed: 24613140
Nature. 2005 Aug 4;436(7051):725-30
pubmed: 16079851
Cancer Res. 2004 Jan 15;64(2):572-80
pubmed: 14744771
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12072-7
pubmed: 11593017
Sci Rep. 2017 Mar 31;7(1):518
pubmed: 28364121
Curr Opin Cell Biol. 2010 Dec;22(6):816-27
pubmed: 20807678
Lancet. 2018 Mar 24;391(10126):1163-1173
pubmed: 29433850
Cancer Discov. 2017 May;7(5):522-538
pubmed: 28202625
Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1164-L1173
pubmed: 28860144
EMBO J. 2000 May 2;19(9):1929-34
pubmed: 10790359
Am J Respir Crit Care Med. 2012 Aug 15;186(4):306-13
pubmed: 22582162
Nature. 2020 Jul;583(7814):127-132
pubmed: 32555459
J Clin Invest. 2013 Mar;123(3):1096-108
pubmed: 23434591
Cell. 2003 May 2;113(3):329-42
pubmed: 12732141
Aging (Albany NY). 2019 Dec 31;12(1):242-259
pubmed: 31891567
Cancer Lett. 2009 Dec 1;286(1):103-13
pubmed: 19070423
Int J Biochem Cell Biol. 2005 May;37(5):961-76
pubmed: 15743671
Gastroenterology. 2015 Oct;149(5):1226-1239.e4
pubmed: 26099527
Nat Med. 2016 Jan;22(1):78-83
pubmed: 26657143
EMBO Mol Med. 2019 Dec;11(12):e10234
pubmed: 31746100
Hepatology. 2018 Jan;67(1):247-259
pubmed: 28802066
Cell. 1995 May 5;81(3):323-30
pubmed: 7736585
Int J Cancer. 2002 Feb 1;97(4):425-31
pubmed: 11802202
J Pharmacol Exp Ther. 2014 Jun;349(3):480-6
pubmed: 24706986
Cell Rep. 2017 Nov 14;21(7):1870-1882
pubmed: 29141219
Sci Rep. 2019 May 8;9(1):7072
pubmed: 31068602
J Clin Invest. 2005 Feb;115(2):209-18
pubmed: 15690074
Cell. 2008 Jun 13;133(6):1019-31
pubmed: 18555778
J Hepatol. 2012 Jul;57(1):108-15
pubmed: 22414764
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20078-83
pubmed: 22135466
Cell. 2008 Jun 13;133(6):1006-18
pubmed: 18555777
EMBO J. 2004 Oct 13;23(20):3973-83
pubmed: 15385960
BMC Cancer. 2018 Jul 5;18(1):716
pubmed: 29976159
Nat Rev Cancer. 2010 Jan;10(1):51-7
pubmed: 20029423
Cell Death Differ. 2018 May;25(5):828-840
pubmed: 29229993
Aging Cell. 2016 Jun;15(3):428-35
pubmed: 26711051
Postgrad Med. 1964 May;35:503-11
pubmed: 14163260
Front Immunol. 2017 Jun 14;8:706
pubmed: 28659930
Hepatology. 2015 Mar;61(3):979-89
pubmed: 25266280
Nat Metab. 2019 Nov;1(11):1074-1088
pubmed: 31799499
Breast Cancer Res. 2000;2(4):252-7
pubmed: 11250717
Mol Biol Cell. 2002 Dec;13(12):4167-78
pubmed: 12475943
J Biol Chem. 2011 Dec 23;286(51):44116-25
pubmed: 22049076
J Surg Res. 2012 Aug;176(2):542-8
pubmed: 22261591
Nat Rev Mol Cell Biol. 2010 May;11(5):353-65
pubmed: 20414257
Oncol Rep. 2011 Dec;26(6):1567-72
pubmed: 21842128
Sci Transl Med. 2014 Apr 9;6(231):231ra47
pubmed: 24718857
Nat Commun. 2017 Feb 23;8:14532
pubmed: 28230051
Nature. 2005 Aug 4;436(7051):660-5
pubmed: 16079837
Lung. 2015 Aug;193(4):605-10
pubmed: 25903793
Nature. 2005 Aug 4;436(7051):642
pubmed: 16079833
Am J Pathol. 2015 Apr;185(4):969-86
pubmed: 25681733
PLoS One. 2012;7(6):e39766
pubmed: 22761893
Int J Oncol. 2014 Jan;44(1):129-36
pubmed: 24173109
Aging (Albany NY). 2015 Sep;7(9):664-72
pubmed: 26399448
Exp Gerontol. 2020 Apr;132:110836
pubmed: 31958492
Aging Cell. 2012 Jun;11(3):378-83
pubmed: 22329645
Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C2-13
pubmed: 24740541
Haematologica. 2020 May;105(5):1339-1350
pubmed: 31582539
Cell Cycle. 2012 Jan 1;11(1):141-50
pubmed: 22185759
EMBO J. 2004 Apr 21;23(8):1834-44
pubmed: 15057274
FASEB J. 2001 Jul;15(9):1625-7
pubmed: 11427507
Mol Aspects Med. 2008 Feb-Apr;29(1-2):130-43
pubmed: 18061252
Cancer Cell. 2010 Apr 13;17(4):376-87
pubmed: 20385362
Nat Immunol. 2008 Sep;9(9):970-80
pubmed: 18711434
Annu Rev Physiol. 2013;75:685-705
pubmed: 23140366
Sci Rep. 2017 Apr 10;7:43299
pubmed: 28393891
J Clin Invest. 2018 Apr 2;128(4):1247-1254
pubmed: 29608140
Med Oncol. 2011 Sep;28(3):796-803
pubmed: 20401641
World J Gastroenterol. 2011 Sep 14;17(34):3922-32
pubmed: 22025881
Circ Res. 2010 Jul 23;107(2):294-304
pubmed: 20558820
Cancer Discov. 2017 Feb;7(2):165-176
pubmed: 27979832
Semin Immunol. 2018 Dec;40:101275
pubmed: 31088710
Biochim Biophys Acta. 1994 Dec 30;1198(2-3):215-30
pubmed: 7819276
Mol Cell Biol. 1996 Mar;16(3):859-67
pubmed: 8622687
Cell. 2008 Feb 8;132(3):363-74
pubmed: 18267069
Am J Respir Cell Mol Biol. 2009 Sep;41(3):332-8
pubmed: 19151320
Nat Commun. 2017 Jun 13;8:15691
pubmed: 28608850
J Clin Invest. 2007 Mar;117(3):524-9
pubmed: 17332879
J Exp Pharmacol. 2018 May 09;10:9-17
pubmed: 29785143
Gastroenterology. 2007 Jun;132(7):2557-76
pubmed: 17570226
N Engl J Med. 2015 Jul 16;373(3):209-19
pubmed: 26030518
Eur Respir J. 2002 May;19(5):794-6
pubmed: 12030715
EMBO Mol Med. 2018 Sep;10(9):
pubmed: 30012580
N Engl J Med. 2011 Sep 22;365(12):1118-27
pubmed: 21992124
Oncogene. 2018 Aug;37(33):4518-4533
pubmed: 29743597
Dev Cell. 2014 Dec 22;31(6):722-33
pubmed: 25499914
Int J Oncol. 2010 Oct;37(4):837-44
pubmed: 20811705
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32311005
Nature. 2019 Oct;574(7777):268-272
pubmed: 31578521
World J Hepatol. 2013 Jul 27;5(7):345-52
pubmed: 23898367
Am J Respir Cell Mol Biol. 2003 Nov;29(5):583-90
pubmed: 12777247
Carcinogenesis. 2012 Jun;33(6):1123-6
pubmed: 22470164
Environ Health Perspect. 1991 Jun;93:59-62
pubmed: 1663451
Clin Cancer Res. 2017 May 15;23(10):2433-2441
pubmed: 28432176
Trends Mol Med. 2010 May;16(5):238-46
pubmed: 20444648
EMBO Mol Med. 2013 Sep;5(9):1367-82
pubmed: 23853104
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Drug Discov Today. 2017 May;22(5):786-795
pubmed: 28111332
Gastroenterology. 2013 Mar;144(3):512-27
pubmed: 23313965
Oncogene. 2020 Mar;39(11):2328-2344
pubmed: 31844251
Science. 2013 May 17;340(6134):864-7
pubmed: 23558171
Mol Cell. 2009 Oct 9;36(1):2-14
pubmed: 19818705
Clin Lung Cancer. 2016 Jan;17(1):80-4
pubmed: 26432508
Nature. 2013 Jul 4;499(7456):97-101
pubmed: 23803760
Oncogene. 2008 May 1;27(20):2801-9
pubmed: 18193093
J Biol Chem. 2007 Oct 19;282(42):30745-53
pubmed: 17702744
Cell. 2013 Nov 21;155(5):1104-18
pubmed: 24238962
Nat Rev Mol Cell Biol. 2019 Mar;20(3):175-193
pubmed: 30655609
Cell. 2003 Jun 13;113(6):703-16
pubmed: 12809602
Nature. 2007 Feb 8;445(7128):656-60
pubmed: 17251933
Pharmacol Rev. 2015 Oct;67(4):1074-95
pubmed: 26419448
Nat Rev Immunol. 2004 Aug;4(8):583-94
pubmed: 15286725
Nat Cell Biol. 2019 Jan;21(1):94-101
pubmed: 30602768
Mol Cell Biol. 2008 Oct;28(20):6302-13
pubmed: 18694962
Immunol Rev. 2007 Dec;220:169-82
pubmed: 17979846
Genes Dev. 1998 Oct 1;12(19):2997-3007
pubmed: 9765202
Hepatology. 2010 Oct;52(4):1310-21
pubmed: 20799354
Cell Death Dis. 2019 Nov 27;10(12):899
pubmed: 31776330
J Biol Chem. 2000 Jul 7;275(27):20847-52
pubmed: 10781609
Indian J Med Microbiol. 2007 Oct;25(4):323-9
pubmed: 18087079
Genes Dev. 2010 Nov 15;24(22):2463-79
pubmed: 21078816
Nat Rev Dis Primers. 2016 Apr 14;2:16018
pubmed: 27158749
Exp Cell Res. 1961 Dec;25:585-621
pubmed: 13905658
Gastroenterology. 2004 Nov;127(5 Suppl 1):S97-103
pubmed: 15508109
Mech Ageing Dev. 2002 Apr 30;123(8):917-26
pubmed: 12044940
Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96
pubmed: 24954210
Physiol Rev. 2019 Apr 1;99(2):1047-1078
pubmed: 30648461
Oncogene. 2017 Jun 15;36(24):3464-3476
pubmed: 28114277
Genes Dev. 1998 Oct 1;12(19):3008-19
pubmed: 9765203
Science. 2007 Jun 22;316(5832):1749-52
pubmed: 17588931
PLoS One. 2010 Jan 19;5(1):e8774
pubmed: 20098744
Nat Cell Biol. 2013 Aug;15(8):978-90
pubmed: 23770676
Nature. 2001 Sep 6;413(6851):86-91
pubmed: 11544531
Cancer Lett. 2013 Dec 1;341(2):224-30
pubmed: 23941832
Cell Cycle. 2013 Nov 1;12(21):3421-32
pubmed: 24047696