Arginine and Arginine/ADMA Ratio Predict 90-Day Mortality in Patients with Out-of-Hospital Cardiac Arrest-Results from the Prospective, Observational COMMUNICATE Trial.
arginine
arginine/ADMA ratio
asymmetric dimethylarginine (ADMA)
cardiac arrest
cardiopulmonary resuscitation
metabolomics
mortality
outcome
prognosis
symmetric dimethylarginine (SDMA)
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
25 Nov 2020
25 Nov 2020
Historique:
received:
09
10
2020
revised:
08
11
2020
accepted:
19
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
2
12
2020
Statut:
epublish
Résumé
(1) Background: In patients with shock, the L-arginine nitric oxide pathway is activated, causing an elevation of nitric oxide, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels. Whether these metabolites provide prognostic information in patients after out-of-hospital cardiac arrest (OHCA) remains unclear. (2) Methods: We prospectively included OHCA patients, recorded clinical parameters and measured plasma ADMA, SDMA and Arginine levels by liquid chromatography tandem mass spectrometry (LC-MS). The primary endpoint was 90-day mortality. (3) Results: Of 263 patients, 130 (49.4%) died within 90 days after OHCA. Compared to survivors, non-survivors had significantly higher levels of ADMA and lower Arginine and Arginine/ADMA ratios in univariable regression analyses. Arginine levels and Arginine/ADMA ratio were significantly associated with 90-day mortality (OR 0.51 (95%CI 0.34 to 0.76),
Identifiants
pubmed: 33255752
pii: jcm9123815
doi: 10.3390/jcm9123815
pmc: PMC7760544
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Gottfried und Julia Bangerter-Rhyner-Stiftung
ID : 8472/ HEG-DSV
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