Vitamin K and Osteoporosis.
Osteocalcin
bone fractures
matrix Gla protein
vitamin K
vitamin K deficiency
vitamin K levels
vitamin K-dependent proteins
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
25 Nov 2020
25 Nov 2020
Historique:
received:
30
09
2020
revised:
31
10
2020
accepted:
14
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
16
4
2021
Statut:
epublish
Résumé
Vitamin K acts as a coenzyme of carboxylase, catalyzing the carboxylation of several vitamin K dependent proteins. Beyond its well-known effects on blood coagulation, it also exerts relevant effects on bone and the vascular system. In this review, we point out the relevance of an adequate vitamin K intake to obtain sufficient levels of carboxylated (active form) vitamin K dependent proteins (such as Osteocalcin and matrix Gla protein) to prevent bone health. Another bone-related action of Vitamin K is being a ligand of the nuclear steroid and xenobiotic receptor (SXR). We also discuss the recommended intake, deficiency, and assessment of vitamin K. Furthermore, we review the few available studies that have as pre-specified outcome bone fractures, indicating that we need more clinical studies to confirm that vitamin K is a potential therapeutic agent for bone fractures.
Identifiants
pubmed: 33255760
pii: nu12123625
doi: 10.3390/nu12123625
pmc: PMC7760385
pii:
doi:
Substances chimiques
Pregnane X Receptor
0
Vitamin K
12001-79-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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