Perioperative Chemotherapy for Liver Metastasis of Colorectal Cancer.

colorectal cancer liver metastasis neoadjuvant/adjuvant chemotherapy and conversion chemotherapy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
26 Nov 2020
Historique:
received: 04 10 2020
revised: 28 10 2020
accepted: 12 11 2020
entrez: 1 12 2020
pubmed: 2 12 2020
medline: 2 12 2020
Statut: epublish

Résumé

The liver is the dominant site of metastasis for patients with colorectal cancer. For those with isolated liver metastases, surgical resection with systemic therapy has led to long-term remission in as high as 80% of patients in well-selected cohorts. This review will focus on how systemic therapy should be integrated with resection of liver metastases; in particular, the use of clinical risk scores based on clinicopathological features that help with patient selection, various approaches to the treatment of micro-metastatic disease (peri-operative versus post-operative chemotherapy), as well as conversion chemotherapy for those with initially upfront unresectable disease will be discussed.

Identifiants

pubmed: 33256170
pii: cancers12123535
doi: 10.3390/cancers12123535
pmc: PMC7760826
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Gloria Chan (G)

Department of Haematology-Oncology, National University Hospital Singapore, National University Cancer Institute, Singapore 119228, Singapore.

Cheng E Chee (CE)

Department of Haematology-Oncology, National University Hospital Singapore, National University Cancer Institute, Singapore 119228, Singapore.

Classifications MeSH