Valproic Acid and Its Amidic Derivatives as New Antivirals against Alphaherpesviruses.
alphaherpesvirus
valnoctamide
valproic acid
valpromide
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
26 11 2020
26 11 2020
Historique:
received:
14
11
2020
revised:
24
11
2020
accepted:
25
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
27
2
2021
Statut:
epublish
Résumé
Herpes simplex viruses (HSVs) are neurotropic viruses with broad host range whose infections cause considerable health problems in both animals and humans. In fact, 67% of the global population under the age of 50 are infected with HSV-1 and 13% have clinically recurrent HSV-2 infections. The most prescribed antiherpetics are nucleoside analogues such as acyclovir, but the emergence of mutants resistant to these drugs and the lack of available vaccines against human HSVs has led to an imminent need for new antivirals. Valproic acid (VPA) is a branched short-chain fatty acid clinically used as a broad-spectrum antiepileptic drug in the treatment of neurological disorders, which has shown promising antiviral activity against some herpesviruses. Moreover, its amidic derivatives valpromide and valnoctamide also share this antiherpetic activity. This review summarizes the current research on the use of VPA and its amidic derivatives as alternatives to traditional antiherpetics in the fight against HSV infections.
Identifiants
pubmed: 33256172
pii: v12121356
doi: 10.3390/v12121356
pmc: PMC7760627
pii:
doi:
Substances chimiques
Amides
0
Antiviral Agents
0
Valproic Acid
614OI1Z5WI
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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