NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles.

Hematologic Neoplasms / immunology Humans Immunotherapy, Adoptive / methods Killer Cells, Natural / immunology
CAR Genetic modification HSC transplantation Immunotherapy KIRs NK cell

Journal

Seminars in hematology
ISSN: 1532-8686
Titre abrégé: Semin Hematol
Pays: United States
ID NLM: 0404514

Informations de publication

Date de publication:
10 2020
Historique:
received: 01 08 2020
revised: 08 09 2020
accepted: 14 10 2020
entrez: 1 12 2020
pubmed: 2 12 2020
medline: 13 4 2021
Statut: ppublish

Résumé

Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic "off-the-shelf" adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.

Identifiants

DOI: 10.1053/j.seminhematol.2020.10.004 PMID: 33256910
pubmed: 33256910
pii: S0037-1963(20)30042-1
doi: 10.1053/j.seminhematol.2020.10.004
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

175-184

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest The authors have no conflicting financial interests.

Auteurs

Simona Caruso (S)

Department Onco-Hematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.

Biagio De Angelis (B)

Department Onco-Hematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.

Simona Carlomagno (S)

University of Genoa, Department of Experimental Medicine (DIMES), Genoa, 16145, Italy.

Francesca Del Bufalo (F)

Department Onco-Hematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.

Simona Sivori (S)

University of Genoa, Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), 16145, Genoa, Italy.

Franco Locatelli (F)

Department Onco-Hematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy; Dipartimento Materno-Infantile e Scienze Urologiche, Sapienza University of Rome, Rome, Italy.

Concetta Quintarelli (C)

Department Onco-Hematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. Electronic address: concetta.quintarelli@opbg.net.

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Classifications MeSH

questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Tumeurs hématologiques › NK cells as adoptive cellular therapy for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › NK cells as adoptive cellular therapy for...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › NK cells as adoptive cellular therapy for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › NK cells as adoptive cellular therapy for...