Time-to-event modeling of hypertension reveals the nonexistence of true controls.
epidemiology
global health
health disparity
human
hypertension
time-to-event
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
10
09
2020
accepted:
13
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Given a lifetime risk of ~90% by the ninth decade of life, it is unknown if there are true controls for hypertension in epidemiological and genetic studies. Here, we compared Bayesian logistic and time-to-event approaches to modeling hypertension. The median age at hypertension was approximately a decade earlier in African Americans than in European Americans or Mexican Americans. The probability of being free of hypertension at 85 years of age in African Americans was less than half that in European Americans or Mexican Americans. In all groups, baseline hazard rates increased until nearly 60 years of age and then decreased but did not reach zero. Taken together, modeling of the baseline hazard function of hypertension suggests that there are no true controls and that controls in logistic regression are cases with a late age of onset.
Identifiants
pubmed: 33258447
doi: 10.7554/eLife.62998
pii: 62998
pmc: PMC7707825
doi:
pii:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHGRI NIH HHS
ID : 1 ZIA HG200362
Pays : United States
Déclaration de conflit d'intérêts
DS, AB, JZ, KE, AD, GC, AA, CR No competing interests declared
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