Homotopic reduction in laser-evoked potential amplitude and laser-pain rating by abdominal acupuncture.
Journal
European journal of pain (London, England)
ISSN: 1532-2149
Titre abrégé: Eur J Pain
Pays: England
ID NLM: 9801774
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
2
12
2020
medline:
28
4
2021
entrez:
1
12
2020
Statut:
ppublish
Résumé
The neural mechanism underlying the analgesic effect of acupuncture is largely unknown. We aimed at investigating the effect of abdominal acupuncture (AA) on the laser-evoked potential (LEP) amplitude and laser-pain rating to stimulation of body parts either homotopic or heterotopic to the treated acupoint. Laser-evoked potentials were recorded from 13 healthy subjects to stimulation of the right wrist (RW), left wrist (LW) and right foot (RF). LEPs were obtained before, during and after the AA stimulation of an abdominal area corresponding to the representation of the RW. Subjective laser-pain rating was collected after each LEP recording. The amplitude of the N2/P2 LEP component was significantly reduced during AA and 15 min after needle removal to both RW (F = 4.14, p = .02) and LW (F = 5.48, p = .008) stimulation, while the N2/P2 amplitude to RF stimulation (F = 0.94, p = .4) remained unchanged. Laser-pain rating was reduced during AA and 15 min after needle removal only to RW stimulation (F = 5.67, p = .007). Our findings showing an AA effect on LEP components to both the ipsilateral and contralateral region homotopic to the treated area, without any LEP change to stimulation of a heterotopic region, suggest that the AA analgesia is mediated by a segmental spinal mechanism. Although abdominal acupuncture has demonstrated to be effective in the reduction in laser-evoked potential (LEP) amplitude and laser-pain rating, the exact mechanism of this analgesic effect is not known. In the current study, we found that treatment of an area in the "turtle representation" of the body led to a topographical pattern of LEP amplitude inhibition that can be mediated by a segmental spinal mechanism.
Sections du résumé
BACKGROUND
The neural mechanism underlying the analgesic effect of acupuncture is largely unknown. We aimed at investigating the effect of abdominal acupuncture (AA) on the laser-evoked potential (LEP) amplitude and laser-pain rating to stimulation of body parts either homotopic or heterotopic to the treated acupoint.
METHODS
Laser-evoked potentials were recorded from 13 healthy subjects to stimulation of the right wrist (RW), left wrist (LW) and right foot (RF). LEPs were obtained before, during and after the AA stimulation of an abdominal area corresponding to the representation of the RW. Subjective laser-pain rating was collected after each LEP recording.
RESULTS
The amplitude of the N2/P2 LEP component was significantly reduced during AA and 15 min after needle removal to both RW (F = 4.14, p = .02) and LW (F = 5.48, p = .008) stimulation, while the N2/P2 amplitude to RF stimulation (F = 0.94, p = .4) remained unchanged. Laser-pain rating was reduced during AA and 15 min after needle removal only to RW stimulation (F = 5.67, p = .007).
CONCLUSION
Our findings showing an AA effect on LEP components to both the ipsilateral and contralateral region homotopic to the treated area, without any LEP change to stimulation of a heterotopic region, suggest that the AA analgesia is mediated by a segmental spinal mechanism.
SIGNIFICANCE
Although abdominal acupuncture has demonstrated to be effective in the reduction in laser-evoked potential (LEP) amplitude and laser-pain rating, the exact mechanism of this analgesic effect is not known. In the current study, we found that treatment of an area in the "turtle representation" of the body led to a topographical pattern of LEP amplitude inhibition that can be mediated by a segmental spinal mechanism.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-667Informations de copyright
© 2020 European Pain Federation - EFIC®.
Références
Bastuji, H., Frot, M., Mazza, S., Perchet, C., Magnin, M., & Garcia-Larrea, L. (2016). Thalamic responses to nociceptive-specific input in humans: Functional dichotomies and thalamo-cortical connectivity. Cerebral Cortex, 26(6), 2663-2676. https://doi.org/10.1093/cercor/bhv106
Biella, G., Sotgiu, M. L., Pellegata, G., Paulesu, E., Castiglioni, I., & Fazio, F. (2001). Acupuncture produces central activations in pain regions. NeuroImage, 14, 60-66. https://doi.org/10.1006/nimg.2001.0798
Bing, Z., Villanueva, L., & Le Bars, D. (1990). Acupuncture and diffuse noxious inhibitory controls: Naloxone-reversible depression of activities of trigeminal convergent neurons. Neuroscience, 37, 809-818. https://doi.org/10.1016/0306-4522(90)90110-P
Bromm, B., & Treede, R. D. (1991). Laser-evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients. Revue Neurologique, 147, 625-643.
Cai, R.-L., Shen, G.-M., Wang, H., & Guan, Y.-Y. (2018). Brain functional connectivity network studies of acupuncture: A systematic review on resting-state fMRI. Journal of Integrative Medicine, 16, 26-33. https://doi.org/10.1016/j.joim.2017.12.002
Choi, E. M., Jiang, F., & Longhurst, J. C. (2012). Point specificity in acupuncture. Chinese Medicine, 7. https://doi.org/10.1186/1749-8546-7-4
Cruccu, G., Pennisi, E., Truini, A., Iannetti, G. D., Romaniello, A., Le Pera, D., De Armas, L., Leandri, M., Manfredi, M., & Valeriani, M. (2003). Unmyelinated trigeminal pathways as assessed by laser stimuli in humans. Brain, 126, 2246-2256. https://doi.org/10.1093/brain/awg227
de Tommaso, M., Delussi, M., Ricci, K., & D'Angelo, G. (2014). Abdominal acupuncture changes cortical responses to nociceptive stimuli in fibromyalgia patients. CNS Neuroscience & Therapeutics. https://doi.org/10.1111/cns.12280
de Tommaso, M., Valeriani, M., Sardaro, M., Serpino, C., Fruscolo, O. D., Vecchio, E., Cerbo, R., & Livrea, P. (2009). Pain perception and laser evoked potentials during menstrual cycle in migraine. The Journal of Headache and Pain, 10, 423-429. https://doi.org/10.1007/s10194-009-0150-2
Dowman, R., Darcey, T., Barkan, H., Thadani, V., & Roberts, D. (2007). Human intracranially-recorded cortical responses evoked by painful electrical stimulation of the sural nerve. NeuroImage, 34, 743-763. https://doi.org/10.1016/j.neuroimage.2006.09.021
Fields, H., Basbaum, A., & Heinricher, M. (2005). Central nervous system mechanisms of pain modulation. In S. McMahon & M. Koltzenburg (Eds.), Textbook of pain (pp. 125-142). .
Frass, M., Strassl, R. P., Friehs, H., Müllner, M., Kundi, M., & Kaye, A. D. (2012). Use and acceptance of complementary and alternative medicine among the general population and medical personnel: A systematic review. Ochsner J, 12, 45-56.
Frot, M., Mauguière, F., Magnin, M., & Garcia-Larrea, L. (2008). Parallel processing of nociceptive A-δ inputs in SII and midcingulate cortex in humans. Journal of Neuroscience, 28, 944-952. https://doi.org/10.1523/jneurosci.2934-07.2008
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003). Brain generators of laser-evoked potentials: From dipoles to functional significance. Neurophysiologie Clinique, 33, 279-292. https://doi.org/10.1016/j.neucli.2003.10.008
Gjerstad, J., Tjølsen, A., Svendsen, F., & Hole, K. (2000). Inhibition of spinal nociceptive responses after intramuscular injection of capsaicin involves activation of noradrenergic and opioid systems. Brain Research, 859(1), 132-136. https://doi.org/10.1016/S0006-8993(00)01970-3
Haanpää, M., Attal, N., Backonja, M., Baron, R., Bennett, M., Bouhassira, D., Cruccu, G., Hansson, P., Haythornthwaite, J. A., Iannetti, G. D., Jensen, T. S., Kauppila, T., Nurmikko, T. J., Rice, A. S. C., Rowbotham, M., Serra, J., Sommer, C., Smith, B. H., & Treede, R. D. (2011). NeuPSIG guidelines on neuropathic pain assessment. Pain, 152, 14-27. https://doi.org/10.1016/j.pain.2010.07.031
Harris, R. E., Zubieta, J. K., Scott, D. J., Napadow, V., Gracely, R. H., & Clauw, D. J. (2009). Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on μ-opioid receptors (MORs). NeuroImage, 47, 1077-1085. https://doi.org/10.1016/j.neuroimage.2009.05.083
Hsieh, J. C., Tu, C. H., Chen, F. P., Chen, M. C., Yeh, T. C., Cheng, H. C., Wu, Y. T., Liu, R. S., & Ho, L. T. (2001). Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: A positron emission tomography study. Neuroscience Letters, 307, 105-108. https://doi.org/10.1016/S0304-3940(01)01952-8
Hui, K. K. S., Liu, J., Makris, N., Gollub, R. L., Chen, A. J. W., Moore, C. I., Kennedy, D. N., Rosen, B. R., & Kwong, K. K. (2000). Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects. Human Brain Mapping, 9, 13-25. https://doi.org/10.1002/(SICI)1097-0193(2000)9:1%3C13:AID-HBM2%3E3.0.CO;2-F
Hui, K. K. S., Liu, J., Marina, O., Napadow, V., Haselgrove, C., Kwong, K. K., Kennedy, D. N., & Makris, N. (2005). The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. NeuroImage, 27, 479-496. https://doi.org/10.1016/j.neuroimage.2005.04.037
Juel, J., Liguori, S., Liguori, A., Valeriani, M., Graversen, C., Olesen, S. S., & Drewes, A. M. (2016). A new method for sham-controlled acupuncture in experimental visceral pain - A randomized, single-blinded study. Pain Practice. https://doi.org/10.1111/papr.12309
Kennedy, D. L., Kemp, H. I., Ridout, D., Yarnitsky, D., & Rice, A. S. C. (2016). Reliability of conditioned pain modulation. Pain, 157(11), 2410-2419. https://doi.org/10.1097/j.pain.0000000000000689
Kunde, V., & Treede, R. D. (1993). Topography of middle-latency somatosensory evoked potentials following painful laser stimuli and non-painful electrical stimuli. Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 88(4), 280-289. https://doi.org/10.1016/0168-5597(93)90052-Q
Le Bars, D., Dickenson, A. H., & Besson, J. M. (1979). Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain, 6, 283-304. https://doi.org/10.1016/0304-3959(79)90049-6
Lorenz, J., & Garcia-Larrea, L. (2003). Contribution of attentional and cognitive factors to laser evoked brain potentials. Neurophysiologie Clinique, 33, 293-301. https://doi.org/10.1016/j.neucli.2003.10.004
Mansour, A., Fox, C. A., Burke, S., Akil, H., & Watson, S. J. (1995). Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS. Journal of Chemical Neuroanatomy, 8, 283-305. https://doi.org/10.1016/0891-0618(95)00055-C
Mense, S. (1983). Basic neurobiologic mechanisms of pain and analgesia. The American Journal of Medicine, 75, 4-14. https://doi.org/10.1016/0002-9343(83)90226-7
Mizoguchi, H., Takagi, H., Watanabe, C., Yonezawa, A., Sato, T., Sakurada, T., & Sakurada, S. (2014). Involvement of multiple μ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission. Peptides, 51, 15-25. https://doi.org/10.1016/j.peptides.2013.10.012
Pazzaglia, C., Liguori, S., Minciotti, I., Testani, E., Tozzi, A. E., Liguori, A., Petti, F., Padua, L., & Valeriani, M. (2015). Abdominal acupuncture reduces laser-evoked potentials in healthy subjects. Clinical Neurophysiology, 126, 1761-1768. https://doi.org/10.1016/j.clinph.2014.11.015
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002). Placebo and opioid analgesia - Imaging a shared neuronal network. Science, 295, 1737-1740. https://doi.org/10.1126/science.1067176
Pomeranz, B., & Chiu, D. (1976). Naloxone blockade of acupuncture analgesia: Endorphin implicated. Life Sciences, 19, 1757-1762. https://doi.org/10.1016/0024-3205(76)90084-9
Treede, R. D., Kenshalo, D. R., Gracely, R. H., & Jones, A. K. P. (1999). The cortical representation of pain. Pain, 79, 105-111. https://doi.org/10.1016/s0304-3959(98)00184-5
Valeriani, M., de Tommaso, M., Restuccia, D., Le Pera, D., Guido, M., Iannetti, G. D., Libro, G., Truini, A., Di Trapani, G., Puca, F., Tonali, P., & Cruccu, G. (2003). Reduced habituation to experimental pain in migraine patients: A CO(2) laser evoked potential study. Pain, 105, 57-64. https://doi.org/10.1016/s0304-3959(03)00137-4
Valeriani, M., Le Pera, D., Niddam, D., Chen, A. C. N., & Arendt-Nielsen, L. (2002). Dipolar modelling of the scalp evoked potentials to painful contact heat stimulation of the human skin. Neuroscience Letters, 318, 44-48. https://doi.org/10.1016/s0304-3940(01)02466-1
Valeriani, M., Pazzaglia, C., Cruccu, G., & Truini, A. (2012). Clinical usefulness of laser evoked potentials. Neurophysiol Clin Neurophysiol, 42, 345-353.
Valeriani, M., Rambaud, L., & Mauguière, F. (1996). Scalp topography and dipolar source modelling of potentials evoked by CO2 laser stimulation of the hand. Electroencephalography and Clinical Neurophysiology, 100, 343-353. https://doi.org/10.1016/0168-5597(96)95625-7
Valeriani, M., Restuccia, D., Barba, C., Le Pera, D., Tonali, P., & Mauguière, F. (2000). Sources of cortical responses to painful CO2 laser skin stimulation of the hand and foot in the human brain. Clinical Neurophysiology, 111, 1103-1112. https://doi.org/10.1016/s1388-2457(00)00273-x
Villanueva, L., Chitour, D., & Le Bars, D. (1986). Involvement of the dorsolateral funiculus in the descending spinal projections responsible for diffuse noxious inhibitory controls in the rat. Journal of Neurophysiology, 56, 1185-1195. https://doi.org/10.1152/jn.1986.56.4.1185
Zhang, W. T., Jin, Z., Cui, G. H., Zhang, K. L., Zhang, L., Zeng, Y. W., Luo, F., Chen, A. C. N., & Han, J. S. (2003). Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: A functional magnetic resonance imaging study. Brain Research, 982, 168-178. https://doi.org/10.1016/s0006-8993(03)02983-4
Zhang, W.-T., Jin, Z., Huang, J., Zhang, L., Zeng, Y.-W., Luo, F., Chen, A. C. N., & Han, J.-S. (2003). Modulation of cold pain in human brain by electric acupoint stimulation: Evidence from fMRI. NeuroReport, 14, 1591-1596. https://doi.org/10.1097/00001756-200308260-00010
Zhang, Y., Li, A., Xin, J., Ren, K., Berman, B. M., Lao, L., & Zhang, R. X. (2018). Electroacupuncture alleviates chemotherapy-induced pain through inhibiting phosphorylation of spinal CaMKII in rats. European Journal of Pain, 22, 679-690. https://doi.org/10.1002/ejp.1132
Zhao, Z. Q. (2008). Neural mechanism underlying acupuncture analgesia. Progress in Neurobiology, 85, 355-375. https://doi.org/10.1016/j.pneurobio.2008.05.004