Molecular and immunological paradigms of hepatocellular carcinoma: Special reference to therapeutic approaches.
combination therapy
hepatocellular carcinoma
immunotherapy
molecular targeted therapy
subclass classification
Journal
Journal of hepato-biliary-pancreatic sciences
ISSN: 1868-6982
Titre abrégé: J Hepatobiliary Pancreat Sci
Pays: Japan
ID NLM: 101528587
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
29
09
2020
revised:
09
10
2020
accepted:
11
10
2020
pubmed:
2
12
2020
medline:
16
10
2021
entrez:
1
12
2020
Statut:
ppublish
Résumé
The development of hepatocellular carcinoma (HCC) is a multistep process with a complex interaction of various genetic backgrounds and the tumor microenvironment. In addition to the development of rational approaches to epidemiologic research, early detection, and diagnosis, considerable progress has been made in systemic treatment with molecular-targeted agents for patients with advanced HCC. Moreover, encouraging reports of recent clinical trials of combination therapy with immune-checkpoint inhibitors (ICIs) has raised high hopes. Each HCC is the result of a unique combination of somatic alterations, including genetic, epigenetic, transcriptomic, and metabolic events, leading to conclusive tumoral heterogeneity. Recent advances in comprehensive genetic analysis have accelerated molecular classification and defined subtypes with specific characteristics, including immune-associated molecular profiles reflecting the immune reactivity in the tumor. In considering the development of therapeutic strategies in combination with immunotherapy, proper interpretation of molecular pathological characterization could lead to effective therapeutic deployment and enable individualization of the management of HCC. Here, we review distinctive molecular alterations in the subtype classification of HCC, current therapies, and representative clinical trials with alternative immune-combination approaches from a molecular pathological point.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-75Subventions
Organisme : Japan Agency for Medical Research and Development
ID : Grant Number JP20fk0210040
Organisme : Japan Society for the Promotion of Science
ID : Grant-in Aid for Challenging Research (20K21627)
Organisme : Japan Society for the Promotion of Science
ID : Grant-in-Aid for Scientific Research (A) 19H01055
Informations de copyright
© 2020 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
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