Linking cortical atrophy to white matter hyperintensities of presumed vascular origin.
Cerebral small vessel disease
cortical thickness
diffusion-weighted imaging
structural connectivity
white matter hyperintensities
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
pubmed:
2
12
2020
medline:
21
8
2021
entrez:
1
12
2020
Statut:
ppublish
Résumé
We examined the relationship between white matter hyperintensities (WMH) and cortical neurodegeneration in cerebral small vessel disease (CSVD) by investigating whether cortical thickness is a remote effect of WMH through structural fiber tract connectivity in a population at increased risk of CSVD. We measured cortical thickness on T1-weighted images and segmented WMH on FLAIR images in 930 participants of a population-based cohort study at baseline. DWI-derived whole-brain probabilistic tractography was used to define WMH connectivity to cortical regions. Linear mixed-effects models were applied to analyze the relationship between cortical thickness and connectivity to WMH. Factors associated with cortical thickness (age, sex, hemisphere, region, individual differences in cortical thickness) were added as covariates. Median age was 64 [IQR 46-76] years. Visual inspection of surface maps revealed distinct connectivity patterns of cortical regions to WMH. WMH connectivity to the cortex was associated with reduced cortical thickness (
Identifiants
pubmed: 33259747
doi: 10.1177/0271678X20974170
pmc: PMC8221767
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1682-1691Références
Front Neurol. 2019 Mar 26;10:238
pubmed: 30972001
Circulation. 2008 Feb 12;117(6):743-53
pubmed: 18212285
Neurology. 2019 Mar 19;92(12):e1298-e1308
pubmed: 30770431
Neurology. 2012 Nov 13;79(20):2025-8
pubmed: 23054230
Brain Behav. 2016 Feb 16;6(3):e00438
pubmed: 26925303
Neuroimage. 2012 Sep;62(3):1924-38
pubmed: 22705374
Neurology. 2015 Apr 21;84(16):1685-92
pubmed: 25809303
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Brain Behav. 2013 Nov;3(6):626-36
pubmed: 24363966
J Cereb Blood Flow Metab. 2020 Mar;40(3):611-621
pubmed: 30782059
Neurology. 2018 Sep 4;91(10):e964-e975
pubmed: 30076276
Stroke. 2016 Feb;47(2):410-6
pubmed: 26696646
Ann Neurol. 2002 Sep;52(3):335-41
pubmed: 12205646
Neurology. 2012 Nov 13;79(20):2029-36
pubmed: 23115210
Cereb Cortex. 2007 Jul;17(7):1550-60
pubmed: 16945978
Stroke. 2015 Feb;46(2):425-32
pubmed: 25572411
J Magn Reson Imaging. 2019 Jan;49(1):152-163
pubmed: 29676856
Arch Gen Psychiatry. 2000 Nov;57(11):1071-6
pubmed: 11074873
Neurology. 2015 Feb 24;84(8):841-8
pubmed: 25632094
Eur J Epidemiol. 2020 Feb;35(2):169-181
pubmed: 31705407
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):1219-25
pubmed: 23933740
Hum Brain Mapp. 2016 Nov;37(11):3858-3872
pubmed: 27258125
Neurobiol Aging. 2005 Apr;26(4):553-9
pubmed: 15653183
Stroke. 2005 Jan;36(1):50-5
pubmed: 15576652
Brain. 2013 Sep;136(Pt 9):2717-26
pubmed: 23864274
Neuroimage. 2018 Apr 15;170:174-181
pubmed: 28315460
BMJ. 2010 Jul 26;341:c3666
pubmed: 20660506
Hum Brain Mapp. 2015 Dec;36(12):4910-25
pubmed: 26769551
Neuroimage. 2015 Oct 1;119:338-51
pubmed: 26163802
Neurology. 2006 Dec 26;67(12):2192-8
pubmed: 17190943
Hum Brain Mapp. 2016 Jan;37(1):300-10
pubmed: 26466741
Nat Rev Neurol. 2018 Jul;14(7):387-398
pubmed: 29802354
Brain. 2011 Jan;134(Pt 1):73-83
pubmed: 21156660
Neuroimage. 2016 Nov 1;141:191-205
pubmed: 27402600
Cereb Cortex. 2006 Aug;16(8):1232-8
pubmed: 16267139
Neurobiol Aging. 2012 Jul;33(7):1156-67
pubmed: 21316813
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):149-53
pubmed: 16421114
PLoS One. 2017 Nov 15;12(11):e0187493
pubmed: 29141024
Neurology. 2001 Apr 10;56(7):921-6
pubmed: 11294930