Impact of gonadectomy on maturational changes in brain volume in adolescent macaques.

Animals Brain / diagnostic imaging Castration Gray Matter / diagnostic imaging Macaca mulatta Magnetic Resonance Imaging Male Sexual Maturation
Adolescent Macaca mulatta Magnetic resonance imaging Prefrontal cortex Testosterone

Journal

Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148

Informations de publication

Date de publication:
02 2021
Historique:
received: 17 04 2019
revised: 29 09 2020
accepted: 12 11 2020
pubmed: 2 12 2020
medline: 1 2 2022
entrez: 1 12 2020
Statut: ppublish

Résumé

Adolescence is a transitional period between childhood and adulthood characterized by significant changes in global and regional brain tissue volumes. It is also a period of increasing vulnerability to psychiatric illness. The relationship between these patterns and increased levels of circulating sex steroids during adolescence remains unclear. The objective of the current study was to determine whether gonadectomy, prior to puberty, alters adolescent brain development in male rhesus macaques. Ninety-six structural MRI scans were acquired from 12 male rhesus macaques (8 time points per animal over a two-year period). Six animals underwent gonadectomy and 6 animals underwent a sham operation at 29 months of age. Mixed-effects models were used to determine whether gonadectomy altered developmental trajectories of global and regional brain tissue volumes. We observed a significant effect of gonadectomy on the developmental trajectory of prefrontal gray matter (GM), with intact males showing peak volumes around 3.5 years of age with a subsequent decline. In contrast, prefrontal GM volumes continued to increase in gonadectomized males until the end of the study. We did not observe a significant effect of gonadectomy on prefrontal white matter or on any other global or regional brain tissue volumes, though we cannot rule out that effects might be detected in a larger sample. Results suggest that the prefrontal cortex is more vulnerable to gonadectomy than other brain regions.

Identifiants

DOI: 10.1016/j.psyneuen.2020.105068 PMID: 33260081 PMC: PMC8121100
pubmed: 33260081
pii: S0306-4530(20)30491-1
doi: 10.1016/j.psyneuen.2020.105068
pmc: PMC8121100
mid: NIHMS1650298
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105068

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD079124
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH100031
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH106440
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH091645
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Rebecca C Knickmeyer (RC)

Michigan State University, Institute for Quantitative Health Science and Engineering, Room 2114, Bio Engineering Facility, 775 Woodlot Dr., East Lansing, MI 48824, USA; University of North Carolina at Chapel Hill, Department of Psychiatry, Campus Box #7160, Chapel Hill, NC 27599-7160, USA. Electronic address: knickmey@msu.edu.

Crystal T Nguyen (CT)

University of North Carolina at Chapel Hill, Department of Biostatistics, Campus Box #7420, Chapel Hill, NC 27599-7420, USA. Electronic address: ctn92@live.unc.edu.

Jeffrey T Young (JT)

University of North Carolina at Chapel Hill, Department of Psychiatry, Campus Box #7160, Chapel Hill, NC 27599-7160, USA. Electronic address: jeffrey@unc.edu.

Anne Haunton (A)

North Carolina School of Science and Mathematics, 1219 Broad St, Durham, NC 27705, USA. Electronic address: alhaunto@nscu.edu.

Michael R Kosorok (MR)

University of North Carolina at Chapel Hill, Department of Biostatistics, Campus Box #7420, Chapel Hill, NC 27599-7420, USA. Electronic address: kosorok@bios.unc.edu.

John H Gilmore (JH)

University of North Carolina at Chapel Hill, Department of Psychiatry, Campus Box #7160, Chapel Hill, NC 27599-7160, USA. Electronic address: john_gilmore@med.unc.edu.

Martin Styner (M)

University of North Carolina at Chapel Hill, Department of Psychiatry, Campus Box #7160, Chapel Hill, NC 27599-7160, USA; University of North Carolina at Chapel Hill, Department of Computer Science, Campus Box #3175, Chapel Hill, NC 27599-3175, USA. Electronic address: styner@email.unc.edu.

Debora A Rothmond (DA)

Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW 2031, Australia. Electronic address: d.rothmond@neura.edu.au.

Pamela L Noble (PL)

Laboratory of Neuropsychology, National Institute for Mental Health, National Institutes of Health, Bethesda, MD 20892-9663, USA. Electronic address: noblep@mail.nih.gov.

Rhoshel Lenroot (R)

University of New Mexico, Department of Psychiatry and Behavioral Sciences, Albuquerque, NM 87131, USA. Electronic address: RLenroot@salud.unm.edu.

Cynthia Shannon Weickert (CS)

School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: c.weickert@neura.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Impact of gonadectomy on maturational changes...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Impact of gonadectomy on maturational changes...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Castration › Impact of gonadectomy on maturational changes...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Impact of gonadectomy on maturational changes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Impact of gonadectomy on maturational changes...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Impact of gonadectomy on maturational changes...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Maturation sexuelle › Impact of gonadectomy on maturational changes...