An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for
Lith genes
bile salts
biliary sludge
cholesterol nucleation and crystallization
gallbladder motility
intestinal cholesterol absorption
lithogenic bile
microlithiasis
mucin gel
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
29 11 2020
29 11 2020
Historique:
received:
06
11
2020
revised:
23
11
2020
accepted:
27
11
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
27
7
2021
Statut:
epublish
Résumé
The cholecystokinin A receptor (CCKAR) is expressed predominantly in the gallbladder and small intestine in the digestive system, where it is responsible for CCK's regulation of gallbladder and small intestinal motility. The effect of CCKAR on small intestinal transit is a physiological response for regulating intestinal cholesterol absorption. The
Identifiants
pubmed: 33260332
pii: genes11121438
doi: 10.3390/genes11121438
pmc: PMC7761502
pii:
doi:
Substances chimiques
Receptor, Cholecystokinin A
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK114516
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126369
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK041296
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106249
Pays : United States
Organisme : NIH HHS
ID : DK106249, DK114516, DK126369, and AA025737
Pays : United States
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