Role of Human Papillomavirus Infection in Head and Neck Cancer in Italy: The HPV-AHEAD Study.
head and neck cancer
human papillomavirus
human papillomavirus diagnosis
oropharyngeal cancer
virus-related cancers
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Nov 2020
29 Nov 2020
Historique:
received:
28
10
2020
revised:
20
11
2020
accepted:
24
11
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
3
12
2020
Statut:
epublish
Résumé
Literature on the role of human papillomavirus (HPV) in head and neck cancer (HNC) in Italy is limited, especially for non-oropharyngeal tumours. Within the context of the HPV-AHEAD study, we aimed to assess the prognostic value of different tests or test algorithms judging HPV carcinogenicity in HNC and factors related to HPV positivity at the European Institute of Oncology. We conducted a retrospective cohort study (2000-2010) on a total of 696 primary HNC patients. Formalin-fixed, paraffin-embedded cancer tissues were studied. All HPV-DNA-positive and a random sample of HPV-DNA-negative cases were subjected to HPV-E6*I mRNA detection and p16
Identifiants
pubmed: 33260360
pii: cancers12123567
doi: 10.3390/cancers12123567
pmc: PMC7760748
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of Health
ID : Ricerca Corrente and 5x1000 funds
Organisme : European Commission HPV-AHEAD
ID : FP7-HEALTH-2011-282562
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