Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study.
liquid paclitaxel
local drug delivery
perfusion catheter
peripheral arterial disease
pre-clinical modeling
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
28 Nov 2020
28 Nov 2020
Historique:
received:
25
09
2020
revised:
17
11
2020
accepted:
24
11
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
3
12
2020
Statut:
epublish
Résumé
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments.
Identifiants
pubmed: 33260517
pii: ph13120434
doi: 10.3390/ph13120434
pmc: PMC7760562
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R15 HL127596
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB028798
Pays : United States
Organisme : American Heart Association
ID : 15SDG25880000
Organisme : NIH HHS
ID : 1R01EB028798
Pays : United States
Organisme : NIH HHS
ID : 1R15HL127596
Pays : United States
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