Small Subcutaneous Soft Tissue Tumors (<5 cm) Can Be Sarcomas and Contrast-Enhanced Ultrasound (CEUS) Is Useful to Identify Potentially Malignant Masses.


Journal

International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455

Informations de publication

Date de publication:
28 11 2020
Historique:
received: 01 10 2020
revised: 17 11 2020
accepted: 25 11 2020
entrez: 2 12 2020
pubmed: 3 12 2020
medline: 16 2 2021
Statut: epublish

Résumé

Subcutaneous masses smaller than 5 cm can be malignant, in contrast with the international guidelines. Ultrasound (US) and magnetic resonance imaging (MRI) are useful to distinguish a potentially malignant mass from the numerous benign soft tissue (ST) lesions. Contrast-enhanced ultrasound (CEUS) was applied in ST tumors, without distinguishing the subcutaneous from the deep lesions. We evaluated CEUS and MRI accuracy in comparison to histology in differentiating malignant from nonmalignant superficial ST masses, 50% smaller than 5 cm. Sensitivity, specificity, and positive and negative predictive values (PPV, NPV) with their 95% confidence intervals (CI) were calculated. Of malignant cases, 44.4% measured ≤5 cm. At univariate analysis, no statistically significant differences emerged between benign and malignant tumors in relation with clinical characteristics, except for relationship with the deep fascia (

Identifiants

pubmed: 33260631
pii: ijerph17238868
doi: 10.3390/ijerph17238868
pmc: PMC7730454
pii:
doi:

Substances chimiques

Contrast Media 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Armanda De Marchi (A)

Department of Imaging, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino, Italy.

Simona Pozza (S)

Department of Imaging, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino, Italy.

Lorena Charrier (L)

Department of Public Health and Pediatrics, University of Turin, Via Santena 5-bis, 10126 Torino, Italy.

Filadelfo Cannone (F)

Radiology Department, Azienda Sanitaria Provinciale di Siracusa, E. Muscatello Hospital, Contrada Granatello, 96011 Augusta, Italy.

Franco Cavallo (F)

Department of Public Health and Pediatrics, University of Turin, Via Santena 5-bis, 10126 Torino, Italy.

Alessandra Linari (A)

Department of Pathology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino, Italy.

Raimondo Piana (R)

Department of Orthopaedic, Traumatology and Rehabilitation, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino, Italy.

Irene Geniò (I)

Department of Imaging, Azienda Ospedaliero Universitaria G. Martino, Via Consolare Valeria 1, 98100 Messina, Italy.

Paolo Balocco (P)

Department of Imaging, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino, Italy.

Alessandro Massè (A)

Department of Orthopaedic, Traumatology and Rehabilitation, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino, Italy.

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Classifications MeSH