Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp.
alternative lengthening of telomeres
cancer stem cells
cell markers
colorectal cancer
dental pulp stem cells
glioma
pluripotency core factors
stem cells
telomerase
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
27 Nov 2020
27 Nov 2020
Historique:
received:
27
10
2020
revised:
24
11
2020
accepted:
26
11
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
3
12
2020
Statut:
epublish
Résumé
The conversion of healthy stem cells into cancer stem cells (CSCs) is believed to underlie tumor relapse after surgical removal and fuel tumor growth and invasiveness. CSCs often arise from the malignant transformation of resident multipotent stem cells, which are present in most human tissues. Some organs, such as the gut and the brain, can give rise to very aggressive types of cancers, contrary to the dental pulp, which is a tissue with a very remarkable resistance to oncogenesis. In this review, we focus on the similarities and differences between gut, brain and dental pulp stem cells and their related CSCs, placing a particular emphasis on both their shared and distinctive cell markers, including the expression of pluripotency core factors. We discuss some of their similarities and differences with regard to oncogenic signaling, telomerase activity and their intrinsic propensity to degenerate to CSCs. We also explore the characteristics of the events and mutations leading to malignant transformation in each case. Importantly, healthy dental pulp stem cells (DPSCs) share a great deal of features with many of the so far reported CSC phenotypes found in malignant neoplasms. However, there exist literally no reports about the contribution of DPSCs to malignant tumors. This raises the question about the particularities of the dental pulp and what specific barriers to malignancy might be present in the case of this tissue. These notable differences warrant further research to decipher the singular properties of DPSCs that make them resistant to transformation, and to unravel new therapeutic targets to treat deadly tumors.
Identifiants
pubmed: 33260962
pii: biology9120426
doi: 10.3390/biology9120426
pmc: PMC7760753
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : MINECO
ID : RYC-2013-13450 and PID2019-104766RB-C21
Organisme : Basque Government/Eusko Jaurkaritza
ID : ELKARTEK KK-2019/00093
Organisme : The University of The Basque Country (UPV/EHU)
ID : GIU16/66, PPGA20/22, UFI 11/44, COLAB19/03 and IKERTU-2020.0155
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