Type I Interferon α/β Receptor-Mediated Signaling Negatively Regulates Antiviral Cytokine Responses in Murine Bone-Marrow-Derived Mast Cells and Protects the Cells from Virus-Induced Cell Death.
Animals
Bone Marrow Cells
/ pathology
Cell Death
Cytokines
/ biosynthesis
Cytoprotection
Down-Regulation
Interleukin-6
/ metabolism
Kinetics
Mast Cells
/ virology
Mice, Knockout
Receptor, Interferon alpha-beta
/ metabolism
Signal Transduction
Time Factors
Tumor Necrosis Factor-alpha
/ metabolism
Vesiculovirus
/ physiology
bone-marrow-derived mast cells
cytokine response
flow cytometry
mast cells
type I interferon
vesicular stomatitis virus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Nov 2020
27 Nov 2020
Historique:
received:
30
09
2020
revised:
10
11
2020
accepted:
23
11
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
5
3
2021
Statut:
epublish
Résumé
Mast cells (MCs) are critical for initiating inflammatory responses to pathogens including viruses. Type I interferons (IFNs) that exert their antiviral functions by interacting with the type I IFN receptor (IFNAR) play a central role in host cellular responses to viruses. Given that virus-induced excessive toxic inflammatory responses are associated with aberrant IFNAR signaling and considering MCs are an early source of inflammatory cytokines during viral infections, we sought to determine whether IFNAR signaling plays a role in antiviral cytokine responses of MCs. IFNAR-intact, IFNAR-blocked, and IFNAR-knockout (IFNAR
Identifiants
pubmed: 33261178
pii: ijms21239041
doi: 10.3390/ijms21239041
pmc: PMC7729593
pii:
doi:
Substances chimiques
Cytokines
0
Ifnar1 protein, mouse
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Receptor, Interferon alpha-beta
156986-95-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 436264-2013
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