Periprosthetic osteolysis: a narrative review.
RANK-RANKL
growth factors
osteoimmunology
periprosthetic osteolysis
Journal
Journal of biological regulators and homeostatic agents
ISSN: 0393-974X
Titre abrégé: J Biol Regul Homeost Agents
Pays: Italy
ID NLM: 8809253
Informations de publication
Date de publication:
Historique:
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
29
1
2021
Statut:
ppublish
Résumé
Periprosthetic osteolysis is still one of the major limitations of prosthetic joints longevity. The process of this "silent" iatrogenic disease involves both mechanical and biological factors that initiate a local immune response in the periprosthetic tissue that eventually lead to implant loosening and failure. There are many causes of the primary aseptic loosening inside the periprosthetic microenvironment, but the most important elements are the wear debris and the cell-particle interactions. Together with implant position, micromotion, bearings, joint fluid pressure, and increased load on the joints drive the pathogenesis of the disease. This narrative review aims to summarise recent studies describing the biological and mechanical factors in the pathogenesis of osteolysis and some of the current pharmacological attempts to "rescue" a failing implant.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
405-417. Congress of the Italian Orthopaedic Research SocietyInformations de copyright
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