UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II.
Microtubule lattice
Microtubule-destabilizing proteins
Microtubules
Tau
UNC-45A
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
22
06
2020
accepted:
18
11
2020
pubmed:
3
12
2020
medline:
22
6
2021
entrez:
2
12
2020
Statut:
epublish
Résumé
In invertebrates, UNC-45 regulates myosin stability and functions. Vertebrates have two distinct isoforms of the protein: UNC-45B, expressed in muscle cells only, and UNC-45A, expressed in all cells and implicated in regulating both non-muscle myosin II (NMII)- and microtubule (MT)-associated functions. Here, we show that,
Identifiants
pubmed: 33262310
pii: jcs.248815
doi: 10.1242/jcs.248815
pmc: PMC7803465
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Molecular Chaperones
0
UNC45A protein, human
0
Myosin Type II
EC 3.6.1.-
Myosins
EC 3.6.4.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM130800
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM126974
Pays : United States
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
Références
Cancer Cell. 2005 Jan;7(1):51-63
pubmed: 15652749
BMC Dev Biol. 2010 Jul 16;10:75
pubmed: 20637071
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13916-21
pubmed: 26512117
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21382-7
pubmed: 21115842
Proc Natl Acad Sci U S A. 1973 Mar;70(3):765-8
pubmed: 4514990
Biophys J. 2014 Aug 5;107(3):654-661
pubmed: 25099804
Cell. 1991 Feb 22;64(4):827-39
pubmed: 1671762
Nature. 1974 Aug 16;250(467):579-80
pubmed: 4845659
Curr Opin Struct Biol. 2002 Dec;12(6):746-53
pubmed: 12504679
J Cell Sci. 2011 Sep 15;124(Pt 18):3164-73
pubmed: 21914819
Mol Biol Cell. 2017 May 15;28(10):1337-1346
pubmed: 28356421
Curr Biol. 2005 Apr 26;15(8):724-31
pubmed: 15854904
Elife. 2016 Jun 09;5:
pubmed: 27278775
J Cell Sci. 2012 Jun 1;125(Pt 11):2561-9
pubmed: 22595526
J Cell Biol. 2006 Jan 16;172(2):245-57
pubmed: 16401721
Nat Rev Cancer. 2015 Feb;15(2):96-109
pubmed: 25614008
Science. 2002 Jan 25;295(5555):669-71
pubmed: 11809970
Biopolymers. 2016 Aug;105(8):547-56
pubmed: 27037673
J Histochem Cytochem. 1973 Jun;21(6):529-39
pubmed: 4358987
Cancer Lett. 2015 Feb 1;357(1):114-120
pubmed: 25444911
Mol Cancer Res. 2019 Feb;17(2):370-383
pubmed: 30322860
Dev Cell. 2012 Oct 16;23(4):729-44
pubmed: 23022035
Curr Biol. 2000 Apr 6;10(7):397-400
pubmed: 10753748
Genome Res. 1999 Jan;9(1):27-43
pubmed: 9927482
Curr Opin Cell Biol. 2007 Feb;19(1):31-5
pubmed: 17184986
J Cell Sci. 2011 Mar 1;124(Pt 5):699-705
pubmed: 21285246
Nat Commun. 2014 Mar 25;5:3510
pubmed: 24667306
Cell. 1996 Feb 23;84(4):623-31
pubmed: 8598048
Cancer Biol Ther. 2019;20(10):1304-1313
pubmed: 31328624
Cell. 1998 Apr 17;93(2):277-87
pubmed: 9568719
J Neurosci. 2006 Mar 22;26(12):3120-9
pubmed: 16554463
Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6):
pubmed: 29858272
Front Cell Dev Biol. 2018 Oct 02;6:95
pubmed: 30333973
Nat Cell Biol. 2019 Sep;21(9):1078-1085
pubmed: 31481790
J Neurosci. 2010 May 26;30(21):7215-26
pubmed: 20505088
Cell Cycle. 2010 Jun 15;9(12):2273
pubmed: 20581435
Genes Dev. 2004 Apr 15;18(8):862-76
pubmed: 15078817
Nat Cell Biol. 2017 May;19(5):480-492
pubmed: 28436967
Dev Biol. 2007 Aug 1;308(1):133-43
pubmed: 17586488
Science. 1999 Oct 22;286(5440):782-5
pubmed: 10531065
J Cell Biol. 1999 Apr 19;145(2):305-15
pubmed: 10209026
Nat Struct Mol Biol. 2005 Apr;12(4):378-9
pubmed: 15750603
FEBS Lett. 1997 Oct 20;416(2):149-52
pubmed: 9369201
BMC Cell Biol. 2010 Sep 17;11:70
pubmed: 20849610
J Immunol. 2015 Nov 15;195(10):4760-70
pubmed: 26438524
MNI Open Res. 2017;1(2):
pubmed: 29355247
J Biol Chem. 2004 Aug 20;279(34):35557-63
pubmed: 15205456
Am J Pathol. 2007 Nov;171(5):1640-9
pubmed: 17872978
Cell. 2013 Jan 17;152(1-2):183-95
pubmed: 23332754
Mol Biol Cell. 2006 Feb;17(2):700-10
pubmed: 16291860
J Cell Biol. 1998 Nov 30;143(5):1215-25
pubmed: 9832550
Dev Dyn. 2002 Aug;224(4):457-60
pubmed: 12203738
J Cell Sci. 2000 Aug;113 ( Pt 16):2821-7
pubmed: 10910766
Trends Cell Biol. 2019 Jun;29(6):452-461
pubmed: 30929793
Curr Opin Cell Biol. 2010 Feb;22(1):96-103
pubmed: 19963362
J Cell Sci. 2002 Nov 1;115(Pt 21):3983-90
pubmed: 12356904
Am J Physiol Cell Physiol. 2011 Apr;300(4):C723-42
pubmed: 21209361
J Cell Biol. 2017 Dec 4;216(12):4053-4072
pubmed: 29055011
Mol Biol Cell. 2018 Mar 1;29(5):632-642
pubmed: 29282275
J Clin Invest. 2012 Mar;122(3):844-58
pubmed: 22293177
J Cell Sci. 2011 Aug 1;124(Pt 15):2642-53
pubmed: 21750190
J Mol Biol. 2011 Sep 23;412(3):365-78
pubmed: 21802425
Hum Mol Genet. 2011 Feb 15;20(4):763-78
pubmed: 21118899
Cytoskeleton (Hoboken). 2016 Sep;73(9):442-60
pubmed: 26887570