Siplizumab, an Anti-CD2 Monoclonal Antibody, Induces a Unique Set of Immune Modulatory Effects Compared to Alemtuzumab and Rabbit Anti-Thymocyte Globulin
Alemtuzumab
/ pharmacology
Animals
Antibodies, Monoclonal, Humanized
/ pharmacology
Antibody-Dependent Cell Cytotoxicity
/ immunology
Antilymphocyte Serum
/ pharmacology
Antineoplastic Agents, Immunological
/ pharmacology
CD2 Antigens
/ antagonists & inhibitors
Cell Line, Tumor
Cells, Cultured
Complement System Proteins
/ immunology
Forkhead Transcription Factors
/ metabolism
Humans
Immunomodulation
/ drug effects
Lymphocyte Activation
/ immunology
Rabbits
Receptors, IgG
/ metabolism
T-Lymphocyte Subsets
/ immunology
T cell biology
costimulation blockade
immune modulation
immunotherapy
siplizumab
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
08
2020
accepted:
14
10
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
25
6
2021
Statut:
epublish
Résumé
Antibodies are commonly used in organ transplant induction therapy and to treat autoimmune disorders. The effects of some biologics on the human immune system remain incompletely characterized and a deeper understanding of their mechanisms of action may provide useful insights for their clinical application. The goal of this study was to contrast the mechanistic properties of siplizumab with Alemtuzumab and rabbit Anti-Thymocyte Globulin (rATG). Mechanistic assay systems investigating antibody-dependent cell-mediated cytotoxicity, antibody-dependent cell phagocytosis and complement-dependent cytotoxicity were used to characterize siplizumab. Further, functional effects of siplizumab, Alemuzumab, and rATG were investigated in allogeneic mixed lymphocyte reaction. Changes in T cell activation, T cell proliferation and frequency of naïve T cells, memory T cells and regulatory T cells induced by siplizumab, Alemtuzumab and rATG in allogeneic mixed lymphocyte reaction were assessed
Identifiants
pubmed: 33262770
doi: 10.3389/fimmu.2020.592553
pmc: PMC7686512
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Antilymphocyte Serum
0
Antineoplastic Agents, Immunological
0
CD2 Antigens
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Receptors, IgG
0
Alemtuzumab
3A189DH42V
Complement System Proteins
9007-36-7
thymoglobulin
D7RD81HE4W
siplizumab
KUW1QG1ZM3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
592553Informations de copyright
Copyright © 2020 Binder, Sellberg, Cvetkovski, Berglund and Berglund.
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