Daytime sleepiness predicts inflammation and ambulatory blood pressure in sleep apnoea.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
08
11
2019
accepted:
19
05
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
3
12
2020
Statut:
epublish
Résumé
Sleepiness in obstructive sleep apnoea is associated with cardiovascular risk; however, the biological mechanisms are not known. This study explored whether those with subjective sleepiness have increased plasma tumour necrosis factor-related protein 1 (C1qTNF1), a novel adipose-derived hormone (adipokine), and 24-h ambulatory blood pressure (ABP) compared to those without sleepiness in newly diagnosed, treatment-naïve participants with obstructive sleep apnoea. Overall, 94 participants were included in the analysis. Participants completed the Epworth Sleepiness Scale (ESS), 24-h ABP was monitored, and plasma C1qTNF1 was measured. Sleepy participants were defined as ESS≥10 and nonsleepy as ESS<10. Multiple linear regression was used to explore differences in C1qTNF1, and 24-h mean arterial pressure (MAP) between sleepy and nonsleepy participants, adjusting for age, sex, body mass index, apnoea-hypopnoea index, and smoking status. C1qTNF1 was significantly higher in sleepy participants (n=57) compared to nonsleepy participants (n=37) (β=0.41 NPX, 95% CI 0.02, 0.80; p=0.04). The 24-h MAP was significantly higher in sleepy participants compared to nonsleepy participants (β=4.06 mmHg, 95% CI 0.36, 7.77; p=0.03). Our findings show that sleepiness is associated with inflammation and higher 24-h MAP in sleep apnoea.
Identifiants
pubmed: 33263040
doi: 10.1183/23120541.00310-2019
pii: 00310-2019
pmc: PMC7682673
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NINR NIH HHS
ID : R00 NR014675
Pays : United States
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: V.M. Pak has nothing to disclose. Conflict of interest: B. Butts has nothing to disclose. Conflict of interest: V. Hertzberg has nothing to disclose. Conflict of interest: N. Collop has nothing to disclose. Conflict of interest: A.A. Quyyumi has nothing to disclose. Conflict of interest: J. Cox has nothing to disclose. Conflict of interest: A. Rogers has nothing to disclose. Conflict of interest: S.B. Dunbar has nothing to disclose.
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