Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency.
COVID-19
Mortality rate
Primary immunodeficiency
Severe viral infection
Journal
Journal of clinical immunology
ISSN: 1573-2592
Titre abrégé: J Clin Immunol
Pays: Netherlands
ID NLM: 8102137
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
23
08
2020
accepted:
16
11
2020
pubmed:
3
12
2020
medline:
12
2
2021
entrez:
2
12
2020
Statut:
ppublish
Résumé
Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.
Identifiants
pubmed: 33263173
doi: 10.1007/s10875-020-00928-x
pii: 10.1007/s10875-020-00928-x
pmc: PMC7707812
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
345-355Références
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
N Engl J Med. 2020 May 7;382(19):1787-1799
pubmed: 32187464
J Infect Dis. 2020 May 11;221(11):1762-1769
pubmed: 32227123
Cell. 2020 Jun 11;181(6):1194-1199
pubmed: 32405102
Science. 2020 Oct 23;370(6515):
pubmed: 32972995
Biology (Basel). 2020 Jul 28;9(8):
pubmed: 32731331
Immunity. 2020 Jun 16;52(6):910-941
pubmed: 32505227
Life Sci. 2020 Oct 1;258:118185
pubmed: 32750438
Lancet HIV. 2020 May;7(5):e314-e316
pubmed: 32304642
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Klin Padiatr. 2020 Sep;232(5):275-278
pubmed: 32767294
J Appl Lab Med. 2020 Nov 1;5(6):1401-1405
pubmed: 32745181
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Lancet Child Adolesc Health. 2020 Sep;4(9):653-661
pubmed: 32593339
J Clin Immunol. 2018 Oct;38(7):816-832
pubmed: 30302726
J Clin Immunol. 2020 Jan;40(1):24-64
pubmed: 31953710
Sci Immunol. 2020 Jul 17;5(49):
pubmed: 32680954
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Pediatr Allergy Immunol. 2021 Jan;32(1):199-201
pubmed: 32683750
Nat Methods. 2016 Feb;13(2):109-10
pubmed: 26820543
JAMA. 2020 Jun 16;323(23):2427-2429
pubmed: 32432657
Clin Infect Dis. 2020 Jul 25;:
pubmed: 32710613
J Int AIDS Soc. 2020 Jul;23(7):e25568
pubmed: 32697865
Pediatr Allergy Immunol. 2020 Jul;31(5):565-569
pubmed: 32319118
J Allergy Clin Immunol. 2020 Jul;146(1):211-213.e4
pubmed: 32333914
Front Immunol. 2020 Jul 03;11:1665
pubmed: 32719688
N Engl J Med. 2020 Jul 9;383(2):187-190
pubmed: 32356945
Infection. 2020 Oct;48(5):681-686
pubmed: 32394344
Am J Hum Genet. 2017 Feb 2;100(2):267-280
pubmed: 28132688
J Allergy Clin Immunol. 2020 Jul;146(1):58-60
pubmed: 32413374
Genet Med. 2015 May;17(5):405-24
pubmed: 25741868
J Allergy Clin Immunol. 2021 Feb;147(2):520-531
pubmed: 32980424
J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1763-1770
pubmed: 30776527
Blood. 2020 Feb 27;135(9):656-667
pubmed: 31942606
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727-11734
pubmed: 32376634
Genet Med. 2019 Jan;21(1):243-251
pubmed: 29921932
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Acta Paediatr. 2020 Aug;109(8):1525-1530
pubmed: 32430964
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Front Oncol. 2020 Aug 19;10:1448
pubmed: 32974166
Clin Exp Allergy. 2020 Dec;50(12):1313-1324
pubmed: 32975865