Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19).
Antibodies, Viral
/ immunology
Antibody Formation
COVID-19
/ immunology
COVID-19 Serological Testing
Child
Female
Humans
Immunoglobulin A
/ immunology
Immunoglobulin G
/ immunology
Immunoglobulin M
/ immunology
Male
SARS-CoV-2
Severity of Illness Index
Spike Glycoprotein, Coronavirus
/ immunology
Systemic Inflammatory Response Syndrome
/ immunology
COVID-19
SARS-COV-2
antibodies
multisystem inflammatory syndrome in children (MIS-C)
pediatric
Journal
Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049
Informations de publication
Date de publication:
28 May 2021
28 May 2021
Historique:
received:
15
09
2020
accepted:
01
12
2020
pubmed:
3
12
2020
medline:
4
6
2021
entrez:
2
12
2020
Statut:
ppublish
Résumé
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike immunoglobulin G (IgG) titers compared with those with severe coronavirus disease 2019, likely reflecting a longer time since the onset of infection in MIS-C patients.
Identifiants
pubmed: 33263756
pii: 6017296
doi: 10.1093/jpids/piaa161
pmc: PMC7799010
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin A
0
Immunoglobulin G
0
Immunoglobulin M
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
669-673Subventions
Organisme : NIAID NIH HHS
ID : R21 AI129531
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142638
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152236
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI070077
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI135091
Pays : United States
Organisme : NICHD NIH HHS
ID : R61 HD105594
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055400
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.