The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective.
Chromatin accessibility
Epigenetics
Neural progenitor
Neurodevelopment
Radial glia
Transcriptional regulation
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
08
2020
accepted:
16
11
2020
revised:
04
11
2020
pubmed:
3
12
2020
medline:
10
4
2021
entrez:
2
12
2020
Statut:
ppublish
Résumé
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism spectrum disorders (ASD), are a large group of disorders in which early insults during brain development result in a wide and heterogeneous spectrum of clinical diagnoses. Mutations in genes coding for chromatin remodelers are overrepresented in NDD cohorts, pointing towards epigenetics as a convergent pathogenic pathway between these disorders. In this review we detail the role of NDD-associated chromatin remodelers during the developmental continuum of progenitor expansion, differentiation, cell-type specification, migration and maturation. We discuss how defects in chromatin remodelling during these early developmental time points compound over time and result in impaired brain circuit establishment. In particular, we focus on their role in the three largest cell populations: glutamatergic neurons, GABAergic neurons, and glia cells. An in-depth understanding of the spatiotemporal role of chromatin remodelers during neurodevelopment can contribute to the identification of molecular targets for treatment strategies.
Identifiants
pubmed: 33263776
doi: 10.1007/s00018-020-03714-5
pii: 10.1007/s00018-020-03714-5
pmc: PMC8004494
doi:
Substances chimiques
Chromatin
0
Histones
0
DNA Helicases
EC 3.6.4.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2517-2563Subventions
Organisme : Simons Foundation Autism Research Initiative (US)
ID : 610264
Références
Curr Opin Neurobiol. 2019 Dec;59:1-8
pubmed: 30856481
Elife. 2016 Jan 27;5:e09531
pubmed: 26814051
Cell Rep. 2017 Apr 11;19(2):335-350
pubmed: 28402856
Development. 2017 Mar 1;144(5):856-865
pubmed: 28126843
J Exp Med. 2017 May 1;214(5):1431-1452
pubmed: 28408410
Mol Psychiatry. 2017 May;22(5):680-688
pubmed: 28194008
Pediatr Res. 2016 Sep;80(3):371-81
pubmed: 27119313
Oncogene. 2003 Feb 20;22(7):1002-11
pubmed: 12592387
Brain Res. 2018 Dec 1;1700:160-169
pubmed: 30194015
Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8246-E8255
pubmed: 30108144
Nature. 2013 Oct 24;502(7472):499-506
pubmed: 24153303
Cell Rep. 2018 Mar 6;22(10):2567-2574
pubmed: 29514086
Acta Neuropathol Commun. 2019 Dec 5;7(1):199
pubmed: 31806049
Cell. 2017 Oct 5;171(2):456-469.e22
pubmed: 28985566
Nat Commun. 2020 Jul 31;11(1):3839
pubmed: 32737294
Mol Cell. 2019 Sep 5;75(5):891-904.e7
pubmed: 31375262
Curr Opin Behav Sci. 2019 Feb;25:57-65
pubmed: 30778395
Genet Med. 2019 Dec;21(12):2723-2733
pubmed: 31239556
Trends Neurosci. 2016 May;39(5):290-299
pubmed: 27032601
Cell Metab. 2014 Apr 1;19(4):605-17
pubmed: 24703693
J Biol Chem. 2013 Jul 26;288(30):21678-87
pubmed: 23770671
F1000Res. 2018 Jan 8;7:23
pubmed: 29375819
Nat Neurosci. 2019 Jul;22(7):1182-1195
pubmed: 31209381
Science. 2009 Oct 9;326(5950):289-93
pubmed: 19815776
Cell Mol Life Sci. 2018 Apr;75(7):1205-1214
pubmed: 29110030
BMC Med Genet. 2007 May 04;8:25
pubmed: 17480217
Genes Dev. 2006 Apr 15;20(8):966-76
pubmed: 16598039
EMBO Mol Med. 2014 Jul 07;6(8):1003-15
pubmed: 25001218
Cell. 1998 May 1;93(3):361-72
pubmed: 9590171
Cell. 1995 Mar 24;80(6):837-45
pubmed: 7697714
Prog Neurobiol. 2007 Sep;83(1):2-23
pubmed: 17580100
Cell Rep. 2020 Jan 7;30(1):173-186.e6
pubmed: 31914384
Nat Neurosci. 2017 Dec;20(12):1694-1707
pubmed: 29184203
Nat Genet. 2005 May;37(5):468-70
pubmed: 15821733
Nature. 2019 Sep;573(7772):61-68
pubmed: 31435019
Brain. 2016 Nov 1;139(11):e64
pubmed: 27474218
J Neurosci. 2013 Apr 10;33(15):6321-32
pubmed: 23575831
Front Mol Neurosci. 2018 Aug 03;11:252
pubmed: 30123105
Neuron. 2014 Apr 2;82(1):94-108
pubmed: 24698270
Genes Dev. 2002 Jul 15;16(14):1779-91
pubmed: 12130538
Oncol Rep. 2017 Jan;37(1):3-9
pubmed: 27841002
Science. 2009 Jul 3;325(5936):90-3
pubmed: 19574390
Cell Rep. 2020 Nov 24;33(8):108416
pubmed: 33238114
Am J Hum Genet. 2018 Jan 4;102(1):156-174
pubmed: 29304373
Cell Rep. 2015 Jan 13;10(2):148-61
pubmed: 25558065
Mol Cell. 2017 Aug 17;67(4):550-565.e5
pubmed: 28803780
Epigenetics. 2018;13(5):536-556
pubmed: 29912614
Genes (Basel). 2020 Mar 26;11(4):
pubmed: 32224912
Nat Commun. 2018 Nov 5;9(1):4619
pubmed: 30397230
Nature. 2016 Sep 29;537(7622):675-679
pubmed: 27602517
J Neurosci. 2012 Apr 4;32(14):4755-61
pubmed: 22492031
Dev Biol. 2009 Jun 15;330(2):440-51
pubmed: 19371735
Cell. 2004 Sep 3;118(5):545-53
pubmed: 15339660
Am J Med Genet A. 2008 Aug 15;146A(16):2053-9
pubmed: 18627065
J Cell Biol. 2018 Jun 4;217(6):1901-1914
pubmed: 29666150
Genome Res. 2019 Apr;29(4):532-542
pubmed: 30858344
Science. 2002 Jul 19;297(5580):365-9
pubmed: 12130776
Neurosci Biobehav Rev. 2016 Sep;68:442-453
pubmed: 27317861
Nat Neurosci. 2018 Sep;21(9):1185-1195
pubmed: 30150662
Neuron. 2004 Jun 24;42(6):947-59
pubmed: 15207239
J Neurosci. 2011 Nov 16;31(46):16570-80
pubmed: 22090484
Nat Commun. 2018 Jan 9;9(1):114
pubmed: 29317619
J Neurodev Disord. 2014;6(1):9
pubmed: 24834135
Development. 2014 Nov;141(22):4343-53
pubmed: 25344075
Mol Cell Biol. 2006 Nov;26(22):8623-38
pubmed: 16954381
J Neurobiol. 2003 Jun;55(3):288-98
pubmed: 12717699
Nat Neurosci. 2018 Jul;21(7):920-931
pubmed: 29915195
Nature. 1998 May 28;393(6683):386-9
pubmed: 9620804
J Comp Neurol. 2019 Jul 1;527(10):1654-1674
pubmed: 30552685
Transl Psychiatry. 2017 Jun 13;7(6):e1152
pubmed: 28608855
Mol Autism. 2017 Mar 20;8:11
pubmed: 28321286
Nat Commun. 2018 Aug 24;9(1):3436
pubmed: 30143612
PLoS Genet. 2017 Jul 13;13(7):e1006886
pubmed: 28704368
Dev Neurosci. 2019;41(3-4):149-165
pubmed: 31982872
PLoS Comput Biol. 2016 May 20;12(5):e1004908
pubmed: 27203237
Mol Cell Neurosci. 2013 Nov;57:130-43
pubmed: 23932971
Dev Cell. 2013 Aug 12;26(3):223-36
pubmed: 23948251
Dev Biol. 2005 Jul 1;283(1):113-27
pubmed: 15893304
Genes Dev. 2000 Aug 1;14(15):1899-907
pubmed: 10921904
Am J Hum Genet. 2014 May 1;94(5):677-94
pubmed: 24768552
Cell Rep. 2016 Oct 11;17(3):653-659
pubmed: 27732843
Eur J Hum Genet. 2010 Apr;18(4):436-41
pubmed: 19904302
Neuron. 2015 Aug 19;87(4):684-98
pubmed: 26291155
Curr Opin Neurobiol. 2013 Dec;23(6):903-13
pubmed: 24090879
Exp Cell Res. 2007 Jun 10;313(10):2077-87
pubmed: 17498694
Dev Cell. 2010 Jan 19;18(1):114-25
pubmed: 20152182
J Neurosci. 2008 May 28;28(22):5794-805
pubmed: 18509041
Int J Neuropsychopharmacol. 2017 Jan 1;20(1):50-57
pubmed: 27516431
Cold Spring Harb Perspect Biol. 2016 Jul 01;8(7):
pubmed: 27371659
Neurotox Res. 2015 Feb;27(2):172-97
pubmed: 25516120
Cereb Cortex. 2015 Oct;25(10):3406-19
pubmed: 25037921
Microbiol Mol Biol Rev. 2000 Jun;64(2):435-59
pubmed: 10839822
Biochim Biophys Acta. 1971 Nov 19;251(2):172-80
pubmed: 11452382
Cell. 2014 Dec 18;159(7):1665-80
pubmed: 25497547
J Med Genet. 1991 Mar;28(3):201-4
pubmed: 2051457
Cell. 2013 Jul 18;154(2):452-64
pubmed: 23870131
Nat Neurosci. 2018 Feb;21(2):218-227
pubmed: 29358666
Synapse. 2008 Jul;62(7):501-7
pubmed: 18435417
Dev Dyn. 2013 Jun;242(6):638-53
pubmed: 23483698
Hum Mutat. 2017 Jun;38(6):637-648
pubmed: 28229514
Biochem J. 2003 Mar 15;370(Pt 3):737-49
pubmed: 12429021
Front Genet. 2020 Sep 03;11:579636
pubmed: 33088284
Nat Protoc. 2018 Oct;13(10):2297-2311
pubmed: 30258174
Mol Cell Proteomics. 2011 Mar;10(3):M110.001198
pubmed: 21076176
Analyst. 2015 May 7;140(9):3057-63
pubmed: 25807213
Transl Psychiatry. 2020 Apr 22;10(1):115
pubmed: 32321908
Sci Transl Med. 2014 Oct 1;6(256):256ra135
pubmed: 25273096
Curr Opin Neurobiol. 2017 Aug;45:113-120
pubmed: 28570864
Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):262-75
pubmed: 25168959
Brain. 2012 Sep;135(Pt 9):2684-98
pubmed: 22961547
Cell. 2008 Nov 14;135(4):749-62
pubmed: 19013282
Nat Neurosci. 2006 Feb;9(2):173-9
pubmed: 16388308
Am J Med Genet A. 2017 Jul;173(7):1821-1830
pubmed: 28498556
Cell. 2011 Jan 21;144(2):200-13
pubmed: 21241891
Sci Rep. 2020 May 12;10(1):7834
pubmed: 32398858
Science. 2010 Jan 8;327(5962):213-6
pubmed: 20056891
Am J Hum Genet. 2007 Mar;80(3):485-94
pubmed: 17273969
J Med Genet. 2012 Aug;49(8):539-43
pubmed: 22889856
Epigenetics Chromatin. 2014 Jun 26;7:12
pubmed: 25028596
Genet Med. 2020 Feb;22(2):389-397
pubmed: 31388190
J Neurosci. 2009 Apr 22;29(16):5051-61
pubmed: 19386901
Cell. 2014 Jul 17;158(2):263-276
pubmed: 24998929
Am J Hum Genet. 2020 Mar 5;106(3):356-370
pubmed: 32109418
Hum Mol Genet. 2019 Dec 15;28(24):4089-4102
pubmed: 31691806
Nat Genet. 1998 Jun;19(2):187-91
pubmed: 9620779
Science. 2007 Oct 19;318(5849):447-50
pubmed: 17761849
Front Neurosci. 2015 Apr 07;9:114
pubmed: 25904839
Am J Hum Genet. 2012 Feb 10;90(2):308-13
pubmed: 22265015
Neurosci Res. 2013 Sep-Oct;77(1-2):42-9
pubmed: 23831515
Cell Res. 2013 Dec;23(12):1396-413
pubmed: 23979016
Transl Psychiatry. 2019 Jan 17;9(1):24
pubmed: 30655503
Neuron. 2013 Jun 19;78(6):986-93
pubmed: 23791194
Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607
pubmed: 31399642
Hum Mol Genet. 2019 Jan 1;28(1):64-73
pubmed: 30239720
J Med Genet. 2018 Aug;55(8):561-566
pubmed: 28866611
Cell. 2012 Nov 9;151(4):918-918.e1
pubmed: 23141546
Zhonghua Kou Qiang Yi Xue Za Zhi. 2006 Jul;41(7):411-5
pubmed: 17067458
Dev Cell. 2010 Feb 16;18(2):191-202
pubmed: 20159591
PLoS One. 2020 May 26;15(5):e0233394
pubmed: 32453735
Nature. 2019 Sep;573(7774):370-374
pubmed: 31462778
Cereb Cortex. 2010 Oct;20(10):2277-86
pubmed: 20534784
J Neurosci. 2013 Apr 10;33(15):6401-11
pubmed: 23575838
Development. 2015 Jan 1;142(1):118-27
pubmed: 25480920
Cell Rep. 2012 Aug 30;2(2):345-57
pubmed: 22854024
J Proteome Res. 2013 Oct 4;12(10):4302-15
pubmed: 23964713
Dev Biol. 2014 Feb 15;386(2):395-407
pubmed: 24362066
Neuron. 2012 Dec 20;76(6):1078-90
pubmed: 23259945
J Neurochem. 2019 Apr;149(1):12-26
pubmed: 30276807
Cell Stem Cell. 2019 Jan 3;24(1):138-152.e8
pubmed: 30609396
J Neurosci. 2015 Apr 1;35(13):5097-108
pubmed: 25834037
Nat Commun. 2019 Jul 4;10(1):2966
pubmed: 31273213
Am J Hum Genet. 2012 Jul 13;91(1):73-82
pubmed: 22726846
J Neurosci. 2014 Feb 19;34(8):2860-70
pubmed: 24553927
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1558-1563
pubmed: 29386386
Noncoding RNA Res. 2018 Mar 02;3(1):20-28
pubmed: 30159436
Transl Psychiatry. 2016 Jan 26;6:e723
pubmed: 26812044
J Biol Chem. 2011 May 6;286(18):16101-8
pubmed: 21454553
Science. 2004 Jan 16;303(5656):343-8
pubmed: 14645854
Epigenomics. 2019 Apr;11(5):563-575
pubmed: 30875234
J Neurosci. 2010 May 26;30(21):7152-67
pubmed: 20505083
Nature. 2007 Oct 11;449(7163):689-94
pubmed: 17851529
Hum Mol Genet. 2009 Jun 1;18(11):1909-23
pubmed: 19279158
Am J Pathol. 2012 Aug;181(2):626-41
pubmed: 22658483
BMC Biol. 2016 Dec 2;14(1):103
pubmed: 27912755
PLoS Genet. 2011 Jun;7(6):e1002084
pubmed: 21695231
Neuroreport. 2018 May 2;29(7):588-593
pubmed: 29570159
Nat Cell Biol. 2009 Feb;11(2):172-82
pubmed: 19151705
Sci Rep. 2017 Jan 10;7:40284
pubmed: 28071689
Nat Commun. 2018 Nov 2;9(1):4595
pubmed: 30389944
Genes Dev. 2012 Nov 15;26(22):2499-511
pubmed: 23105005
Cereb Cortex. 2017 Dec 1;27(12):5696-5714
pubmed: 29117290
Nat Commun. 2021 Sep 1;12(1):4087
pubmed: 34471112
Blood. 2012 Dec 6;120(24):4720-32
pubmed: 23018638
Development. 2014 Feb;141(3):604-616
pubmed: 24449838
Nat Neurosci. 2009 Jul;12(7):829-38
pubmed: 19503085
J Immunol. 2007 Jan 1;178(1):345-51
pubmed: 17182572
Autism Res. 2012 Dec;5(6):385-97
pubmed: 23055267
Neuron. 2009 Sep 10;63(5):600-13
pubmed: 19755104
Mol Biol Cell. 2018 Jan 15;29(2):209-219
pubmed: 29142070
Neuron. 2012 Jan 26;73(2):292-303
pubmed: 22284184
Brain Struct Funct. 2020 Dec;225(9):2701-2716
pubmed: 32975655
Mol Cell. 2010 Apr 23;38(2):165-78
pubmed: 20346720
Mol Psychiatry. 2015 Mar;20(3):320-8
pubmed: 24662927
Nat Rev Neurosci. 2007 Jun;8(6):427-37
pubmed: 17514196
Trends Genet. 2004 Apr;20(4):214-20
pubmed: 15041176
Am J Med Genet A. 2014 Jul;164A(7):1744-9
pubmed: 24838796
Front Genet. 2020 May 12;11:450
pubmed: 32477404
Curr Opin Neurobiol. 2019 Dec;59:95-101
pubmed: 31163286
Elife. 2013 Dec 24;2:e01305
pubmed: 24368733
J Med Genet. 2016 Mar;53(3):152-62
pubmed: 26543203
Arch Neurol. 2001 Mar;58(3):365-70
pubmed: 11255439
Am J Hum Genet. 2006 Aug;79(2):370-7
pubmed: 16826528
Dev Cell. 2009 Nov;17(5):674-86
pubmed: 19922872
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23242-23251
pubmed: 32503914
Eur J Hum Genet. 2013 Mar;21(3):343-6
pubmed: 22872102
Dev Neurobiol. 2011 Jan 1;71(1):45-61
pubmed: 21154909
Dev Cell. 2013 May 13;25(3):256-69
pubmed: 23643363
PLoS Genet. 2009 Sep;5(9):e1000650
pubmed: 19763162
Nat Genet. 2004 Sep;36(9):955-7
pubmed: 15300250
Nat Commun. 2017 Mar 20;8:14758
pubmed: 28317875
Dev Biol. 2016 May 15;413(2):173-87
pubmed: 27067865
JAMA. 2018 Feb 6;319(5):474-482
pubmed: 29411031
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Development. 2004 Jun;131(12):2791-801
pubmed: 15142975
Annu Rev Biochem. 2009;78:273-304
pubmed: 19355820
Nature. 2019 Mar;567(7749):535-539
pubmed: 30867594
Nat Genet. 2012 Mar 18;44(4):376-8
pubmed: 22426308
Protein Sci. 2016 Nov;25(11):1965-1976
pubmed: 27576763
Ann Neurol. 2018 Feb;83(2):433-436
pubmed: 29360170
Nature. 2013 Sep 19;501(7467):373-9
pubmed: 23995685
Nat Rev Genet. 2018 May;19(5):253-268
pubmed: 29398702
Mol Neurobiol. 2019 Jun;56(6):4440-4454
pubmed: 30334186
Nature. 2011 Jun 29;475(7357):497-500
pubmed: 21716289
Nat Commun. 2018 May 29;9(1):2112
pubmed: 29844320
Cell. 1999 Oct 29;99(3):247-57
pubmed: 10555141
Am J Hum Genet. 2018 Mar 1;102(3):468-479
pubmed: 29429572
Nature. 2014 Jul 17;511(7509):344-7
pubmed: 24896178
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22331-22340
pubmed: 32839322
Am J Hum Genet. 2013 Feb 7;92(2):210-20
pubmed: 23332918
PLoS One. 2012;7(4):e35354
pubmed: 22532851
Mol Cell Biol. 2010 Apr;30(8):1997-2005
pubmed: 20123967
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10635-40
pubmed: 12953102
Am J Hum Genet. 2013 Jul 11;93(1):124-31
pubmed: 23746550
Neuron. 2016 Jul 20;91(2):341-55
pubmed: 27373831
Science. 2019 May 10;364(6440):
pubmed: 31073041
Cell Rep. 2013 Jun 27;3(6):1815-23
pubmed: 23770240
Mol Syndromol. 2012 Apr;2(3-5):202-212
pubmed: 22670141
Neuron. 2009 Dec 10;64(5):678-91
pubmed: 20005824
PLoS Genet. 2006 Apr;2(4):e58
pubmed: 16628246
Cell Metab. 2017 Apr 4;25(4):823-837.e8
pubmed: 28380375
Prog Neurobiol. 2018 Jun - Aug;165-167:66-86
pubmed: 29444459
Antioxid Redox Signal. 2013 Oct 20;19(12):1305-20
pubmed: 23541030
Front Cell Neurosci. 2011 Jul 14;5:14
pubmed: 21808605
Epigenomics. 2015;7(4):641-52
pubmed: 26111034
Trends Neurosci. 2015 Feb;38(2):117-25
pubmed: 25529141
Stem Cell Reports. 2019 Jul 9;13(1):115-131
pubmed: 31204298
Hum Mol Genet. 2019 Nov 21;28(R2):R254-R264
pubmed: 31595951
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):841-6
pubmed: 22215600
Nat Commun. 2019 Oct 30;10(1):4928
pubmed: 31666522
Clin Genet. 1996 Oct;50(4):217-9
pubmed: 9001802
Nat Rev Neurosci. 2019 Sep;20(9):563-572
pubmed: 31222186
Genes Dev. 2001 Feb 15;15(4):428-43
pubmed: 11230151
Dev Biol. 2006 Oct 15;298(2):354-67
pubmed: 16950240
Nat Commun. 2018 Aug 28;9(1):3374
pubmed: 30154464
Stem Cell Reports. 2016 Sep 13;7(3):454-470
pubmed: 27546533
Cell. 2014 Nov 6;159(4):775-88
pubmed: 25417155
Nat Genet. 2009 May;41(5):535-43
pubmed: 19377476
Nat Comput Sci. 2021 Feb;1(2):120-127
pubmed: 35356158
Hum Mol Genet. 2020 Sep 30;29(R1):R42-R50
pubmed: 32766754
Cell Stem Cell. 2007 Oct 11;1(4):443-57
pubmed: 18371380
Clin Chim Acta. 1995 Jan 16;233(1-2):39-45
pubmed: 7758201
Eur J Hum Genet. 2020 Oct;28(10):1422-1431
pubmed: 32483341
J Clin Endocrinol Metab. 2013 Apr;98(4):E737-43
pubmed: 23526466
Nat Genet. 2001 Dec;29(4):465-8
pubmed: 11704759
Nat Genet. 1999 Oct;23(2):185-8
pubmed: 10508514
Nature. 2009 Aug 13;460(7257):863-8
pubmed: 19587682
Transcription. 2011 Nov-Dec;2(6):244-53
pubmed: 22223048
Neuron. 2008 Feb 7;57(3):378-92
pubmed: 18255031
Genes Dev. 2009 Jul 15;23(14):1625-30
pubmed: 19605684
J Am Chem Soc. 2016 Sep 28;138(38):12304-7
pubmed: 27610633
Am J Hum Genet. 2014 Nov 6;95(5):490-508
pubmed: 25307298
Am J Med Genet A. 2019 May;179(5):852-856
pubmed: 30806031
Nature. 2017 Feb 23;542(7642):433-438
pubmed: 28135719
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2521-6
pubmed: 20133783
Eukaryot Cell. 2006 Oct;5(10):1738-47
pubmed: 17030999
Genet Med. 2019 Mar;21(3):572-579
pubmed: 29907796
Nat Neurosci. 2017 Aug;20(8):1062-1073
pubmed: 28671691
Neuron. 1993 Feb;10(2):201-12
pubmed: 8439409
Nat Rev Neurosci. 2013 Nov;14(11):755-69
pubmed: 24105342
J Neurol. 2016 Oct;263(10):1939-45
pubmed: 27383641
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14097-102
pubmed: 14617767
Am J Hum Genet. 2015 Mar 5;96(3):507-13
pubmed: 25728777
Commun Biol. 2020 Jun 1;3(1):278
pubmed: 32483278
Cell. 2015 Jul 16;162(2):375-390
pubmed: 26186191
BMC Med Genet. 2017 Jun 15;18(1):68
pubmed: 28619046
Nat Neurosci. 2016 Nov;19(11):1477-1488
pubmed: 27694995
Cell. 2013 Jun 6;153(6):1281-95
pubmed: 23706625
Arch Biochem Biophys. 1985 Nov 15;243(1):125-34
pubmed: 4062299
Elife. 2015 Jan 03;4:
pubmed: 25556700
Nat Rev Genet. 2001 Apr;2(4):292-301
pubmed: 11283701
Hum Mol Genet. 2014 Sep 1;23(17):4674-85
pubmed: 24760766
JAMA Pediatr. 2017 Oct 1;171(10):948-956
pubmed: 28828483
Curr Pharm Des. 2013;19(28):5051-64
pubmed: 23448461
Cereb Cortex. 2020 Jan 10;30(1):256-268
pubmed: 31038696
Hum Genet. 2017 Mar;136(3):297-305
pubmed: 28124119
Dev Dyn. 2008 Aug;237(8):2256-67
pubmed: 18651664
Front Mol Neurosci. 2018 Jun 15;11:208
pubmed: 29962935
Cereb Cortex. 2018 Jun 1;28(6):2192-2206
pubmed: 29668850
Cell Stem Cell. 2020 Jul 2;27(1):35-49.e6
pubmed: 32619517
Exp Hematol. 2017 Apr;48:58-71.e15
pubmed: 27931852
J Biol Chem. 2011 Aug 12;286(32):28019-25
pubmed: 21685381
Sci Transl Med. 2015 May 6;7(286):286ra66
pubmed: 25947161
Stem Cell Res. 2020 Jul;46:101867
pubmed: 32535494
Nature. 2012 Sep 13;489(7415):313-7
pubmed: 22885700
Brain Sci. 2017 May 14;7(5):
pubmed: 28505103
J Neurosci. 2020 Feb 12;40(7):1514-1526
pubmed: 31911459
Neuron. 2018 Oct 24;100(2):294-313
pubmed: 30359598
Mol Neurobiol. 2017 Aug;54(6):4618-4635
pubmed: 27392482
Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):327-32
pubmed: 25169651
Front Neurosci. 2018 Apr 09;12:226
pubmed: 29686607
Dev Biol. 2014 Jan 15;385(2):230-41
pubmed: 24247009
Science. 2015 Sep 25;349(6255):1489-94
pubmed: 26404826
Nat Genet. 2002 Apr;30(4):441-5
pubmed: 11889467
Dev Biol. 2006 Jan 15;289(2):372-83
pubmed: 16330018
Am J Hum Genet. 2011 Oct 7;89(4):551-63
pubmed: 21981781
PLoS Genet. 2016 Sep 09;12(9):e1006274
pubmed: 27611684
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6132-7
pubmed: 9177182
Cell Rep. 2020 Jun 30;31(13):107838
pubmed: 32610139
Biochem Soc Trans. 2008 Aug;36(Pt 4):575-83
pubmed: 18631120
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8384-9
pubmed: 15155908
Cell Metab. 2011 Dec 7;14(6):724-38
pubmed: 22152301
Annu Rev Biochem. 2006;75:243-69
pubmed: 16756492
BMC Med Genet. 2019 Jan 11;20(1):12
pubmed: 30635043
Neuron. 2007 Jul 19;55(2):201-15
pubmed: 17640523
Curr Opin Neurobiol. 2014 Jun;26:79-87
pubmed: 24440413
Hum Mutat. 2012 Nov;33(11):1520-5
pubmed: 22715153
Nat Neurosci. 2016 Feb;19(2):335-46
pubmed: 26727548
Cell. 2014 Oct 23;159(3):635-46
pubmed: 25307933
Trends Genet. 2020 Mar;36(3):160-176
pubmed: 32007289
Mol Cell Biol. 2016 Nov 14;36(23):2995-3008
pubmed: 27669733
Mol Cell Neurosci. 2018 Mar;87:1-3
pubmed: 29248671
Mol Cell. 2003 Dec;12(6):1565-76
pubmed: 14690608
PLoS One. 2011;6(9):e24515
pubmed: 21931736
Nat Commun. 2021 May 21;12(1):3014
pubmed: 34021162
Nat Commun. 2016 May 26;7:11725
pubmed: 27226355
J Clin Invest. 2005 Feb;115(2):258-67
pubmed: 15668733
Mol Psychiatry. 2021 Dec;26(12):7560-7580
pubmed: 34433918
Chem Rev. 2015 Mar 25;115(6):2274-95
pubmed: 25424540
Mol Cell Biol. 2010 May;30(10):2485-97
pubmed: 20212086
Nat Rev Mol Cell Biol. 2007 Dec;8(12):983-94
pubmed: 18037899
Mol Cell Biol. 2011 Jun;31(11):2174-83
pubmed: 21444719
Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):302-14
pubmed: 25169058
Cold Spring Harb Perspect Med. 2017 Apr 3;7(4):
pubmed: 28096241
Mol Autism. 2018 Dec 19;9:65
pubmed: 30574290
Hum Mutat. 2013 Nov;34(11):1519-28
pubmed: 23929686
Nucleus. 2016 Jul 3;7(4):388-404
pubmed: 27429206
Curr Opin Neurobiol. 2017 Apr;43:149-155
pubmed: 28399421
Front Mol Neurosci. 2019 Jan 14;11:481
pubmed: 30692911
Cell Rep. 2013 Mar 28;3(3):931-45
pubmed: 23523356
Genes (Basel). 2019 Mar 29;10(4):
pubmed: 30934924
Cell Rep. 2016 Nov 1;17(6):1683-1698
pubmed: 27806305
Neuron. 2012 Apr 12;74(1):122-35
pubmed: 22500635
Hum Mol Genet. 2013 Jun 1;22(11):2200-13
pubmed: 23418308
Genes Cells. 2015 Feb;20(2):108-20
pubmed: 25441120
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2259-64
pubmed: 19171905
Nat Commun. 2019 Mar 20;10(1):1289
pubmed: 30894531
Mol Brain. 2011 Jan 19;4:5
pubmed: 21247469
Mol Cell. 2016 Jun 2;62(5):657-64
pubmed: 27259198
Meta Gene. 2014 Jul 05;2:469-78
pubmed: 25606431
Dis Model Mech. 2009 Jul-Aug;2(7-8):412-8
pubmed: 19535498
Elife. 2017 Jul 11;6:
pubmed: 28695822
Cell Reprogram. 2011 Feb;13(1):1-6
pubmed: 20979531
Nat Genet. 2012 Apr 29;44(6):639-41
pubmed: 22544363
Neural Plast. 2011;2011:921680
pubmed: 21826280
Neuron. 2013 Oct 30;80(3):613-23
pubmed: 24183014
Exp Neurol. 2016 Sep;283(Pt A):39-48
pubmed: 27240521
Neurol Sci. 2016 May;37(5):829-31
pubmed: 26792009
Nature. 2014 Nov 13;515(7526):209-15
pubmed: 25363760
Nat Genet. 2012 Mar 18;44(4):379-80
pubmed: 22426309
J Am Chem Soc. 2014 Aug 27;136(34):11864-6
pubmed: 25099620
Orphanet J Rare Dis. 2019 Nov 14;14(1):255
pubmed: 31727177
Stem Cell Reports. 2018 Nov 13;11(5):1211-1225
pubmed: 30392976
Sci Rep. 2016 Oct 21;6:35756
pubmed: 27767173
Cell. 2006 Sep 8;126(5):905-16
pubmed: 16959570
Crit Rev Clin Lab Sci. 2016;53(3):147-65
pubmed: 26758403
J Biol Chem. 2010 Jun 25;285(26):20234-41
pubmed: 20404330
J Neuropathol Exp Neurol. 1988 Mar;47(2):166-88
pubmed: 3339373
J Biol Chem. 2004 May 7;279(19):20369-77
pubmed: 14990586
Am J Med Genet A. 2010 Dec;152A(12):3057-67
pubmed: 21086493
Am J Med Genet A. 2012 Aug;158A(8):1865-76
pubmed: 22711679
Ann Neurol. 2002 Sep;52(3):285-96
pubmed: 12205640
Am J Med Genet. 2001 Mar 15;99(3):190-5
pubmed: 11241488
Genes Dev. 2020 Apr 1;34(7-8):580-597
pubmed: 32115408
Genes Dev. 2001 Sep 15;15(18):2343-60
pubmed: 11562345
Prenat Diagn. 2020 Aug;40(9):1185-1192
pubmed: 32386259
Mol Cell Biol. 2007 Dec;27(23):8243-58
pubmed: 17893328
Dev Cell. 2018 Jun 18;45(6):753-768.e8
pubmed: 29920279
Sci Rep. 2015 Oct 26;5:15484
pubmed: 26499080
Development. 2015 Nov 15;142(22):3805-9
pubmed: 26577203
Sci Rep. 2015 Nov 06;5:16256
pubmed: 26543002
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5015-20
pubmed: 21383153
Development. 2000 Jun;127(12):2537-48
pubmed: 10821753
J Neurosci. 2010 Dec 15;30(50):16796-808
pubmed: 21159951
Dis Model Mech. 2017 Feb 1;10(2):119-126
pubmed: 28093507
Dev Cell. 2018 Mar 26;44(6):709-724.e6
pubmed: 29551561
Leuk Lymphoma. 2015 Feb;56(2):527-8
pubmed: 24844365
Nat Neurosci. 2018 Sep;21(9):1218-1228
pubmed: 30104731
J Clin Invest. 2013 May;123(5):2049-63
pubmed: 23563309
Int J Mol Sci. 2020 Sep 17;21(18):
pubmed: 32957495
Nucleic Acids Res. 2018 Jun 1;46(10):4950-4965
pubmed: 29554304
Am J Hum Genet. 2012 Aug 10;91(2):358-64
pubmed: 22795537
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14075-80
pubmed: 20651253
Genet Med. 2019 Apr;21(4):850-860
pubmed: 30245513
J Biol Chem. 2002 Feb 1;277(5):3614-21
pubmed: 11723112
J Clin Invest. 2020 Mar 2;130(3):1431-1445
pubmed: 31794431
EMBO J. 2013 May 29;32(11):1598-612
pubmed: 23624931
Am J Hum Genet. 2015 Mar 5;96(3):498-506
pubmed: 25728775
Hum Mol Genet. 2020 May 28;29(8):1274-1291
pubmed: 32142125
J Biol Chem. 2013 Sep 13;288(37):26473-9
pubmed: 23861393
Hum Mol Genet. 2009 Mar 1;18(5):966-77
pubmed: 19088125
Biochemistry. 2006 May 2;45(17):5671-7
pubmed: 16634648
Dialogues Clin Neurosci. 2009;11(3):281-95
pubmed: 19877496
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7876-81
pubmed: 19380719
Stem Cell Reports. 2018 Jun 5;10(6):1734-1750
pubmed: 29779894
PLoS Biol. 2020 May 13;18(5):e3000705
pubmed: 32401820
Nat Neurosci. 2013 Nov;16(11):1576-87
pubmed: 24097039
Front Cell Neurosci. 2019 Aug 20;13:381
pubmed: 31481878
J Cell Biol. 2012 Mar 19;196(6):801-10
pubmed: 22412018
J Biol Chem. 2011 May 27;286(21):18363-8
pubmed: 21454653
Cell. 2011 Sep 16;146(6):1016-28
pubmed: 21925322
Development. 2010 Jun;137(11):1907-17
pubmed: 20460369
Mol Cell. 2019 Nov 21;76(4):660-675.e9
pubmed: 31542297
Hum Mutat. 2010 Aug;31(8):889-900
pubmed: 20506206
Nature. 2014 Nov 13;515(7526):216-21
pubmed: 25363768
Dev Cell. 2012 Apr 17;22(4):871-8
pubmed: 22516202
Semin Cell Dev Biol. 2021 Mar;111:32-39
pubmed: 32499191
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt B):306-327
pubmed: 29309830
Am J Med Genet. 1980;7(1):5-9
pubmed: 7211953
Nat Commun. 2017 Jan 18;8:14077
pubmed: 28098153
Trends Neurosci. 2011 Jan;34(1):41-50
pubmed: 21129791
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15957-62
pubmed: 20798045
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4468-77
pubmed: 25294932
Glia. 2011 Sep;59(9):1215-36
pubmed: 21584869
Nat Genet. 2004 Jun;36(6):631-5
pubmed: 15146186
J Biol Chem. 2000 Oct 20;275(42):32871-8
pubmed: 10921920
Nature. 2012 Apr 11;485(7398):376-80
pubmed: 22495300
Am J Med Genet. 1999 Jul 30;85(3):216-20
pubmed: 10398231
Epigenetics Chromatin. 2013 Dec 13;6(1):42
pubmed: 24330833
J Neurochem. 2001 May;77(4):1145-56
pubmed: 11359880
Nat Genet. 2013 Jul;45(7):825-30
pubmed: 23708187
Microbiol Mol Biol Rev. 2006 Sep;70(3):789-829
pubmed: 16959969
Cell Rep. 2015 Dec 1;13(9):1842-54
pubmed: 26655900
Neuron. 2019 Feb 20;101(4):648-661.e4
pubmed: 30679017
Nat Rev Cancer. 2011 Jul 07;11(8):588-96
pubmed: 21734722
Mol Cell Biol. 1999 Oct;19(10):7237-44
pubmed: 10490658
J Mol Biol. 1997 Sep 26;272(3):301-11
pubmed: 9325091
Am J Hum Genet. 2013 Jan 10;92(1):114-25
pubmed: 23246292
Nature. 2010 Nov 11;468(7321):263-9
pubmed: 21068835
Mol Autism. 2020 Oct 5;11(1):74
pubmed: 33023670
J Biomed Sci. 2019 Oct 20;26(1):79
pubmed: 31629407
Elife. 2019 Nov 18;8:
pubmed: 31736464
Mol Cell Proteomics. 2007 May;6(5):812-9
pubmed: 17267393
Nat Genet. 2009 Feb;41(2):246-50
pubmed: 19151716
Nat Neurosci. 2016 May;19(5):678-689
pubmed: 26928066
Mamm Genome. 2010 Apr;21(3-4):130-42
pubmed: 20111866
Science. 2020 Jan 24;367(6476):
pubmed: 31974223
Semin Cell Dev Biol. 2018 Apr;76:86-100
pubmed: 28918121
J Pediatr. 1988 Oct;113(4):703-6
pubmed: 3171794
Curr Opin Genet Dev. 2004 Oct;14(5):461-9
pubmed: 15380235
Glia. 2007 Nov 15;55(15):1601-9
pubmed: 17823967
Science. 2004 Oct 8;306(5694):279-83
pubmed: 15345777
Am J Hum Genet. 2019 Apr 4;104(4):685-700
pubmed: 30929737
Am J Hum Genet. 2019 Jan 3;104(1):164-178
pubmed: 30580808
Cell Stem Cell. 2014 Jun 5;14(6):762-75
pubmed: 24905166
Cell Rep. 2015 Mar 3;10(8):1297-309
pubmed: 25732821
Cereb Cortex. 2020 Mar 14;30(3):1382-1392
pubmed: 31504276
Curr Opin Cell Biol. 2005 Dec;17(6):664-71
pubmed: 16226449
Am J Hum Genet. 2017 Jun 1;100(6):907-925
pubmed: 28575647
Nat Chem Biol. 2018 Nov;14(11):995-1004
pubmed: 30177848
Trends Neurosci. 2020 Aug;43(8):608-621
pubmed: 32507511
Hum Mol Genet. 2000 Oct;9(16):2395-402
pubmed: 11005794
Trends Cell Biol. 2015 Oct;25(10):623-632
pubmed: 26410408
Front Neural Circuits. 2012 May 31;6:33
pubmed: 22666189
J Biol Chem. 2002 Oct 25;277(43):41038-45
pubmed: 12192000
J Pediatr. 1974 Apr;84(4):547-52
pubmed: 4366187
Neurology. 2015 Mar 3;84(9):951-8
pubmed: 25672921
Stem Cells. 2015 Jun;33(6):1794-806
pubmed: 25786798
Science. 2016 Mar 25;351(6280):1443-6
pubmed: 26940868
Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233
pubmed: 30150385
Clin Dysmorphol. 1993 Jul;2(3):232-6
pubmed: 8287185
J Hum Genet. 2015 Jun;60(6):339-42
pubmed: 25787343
Nat Commun. 2019 Sep 11;10(1):4112
pubmed: 31511512
J Nutr. 2006 Jul;136(7):1763-5
pubmed: 16772434
Dev Biol. 2016 Mar 1;411(1):15-24
pubmed: 26806701
Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51
pubmed: 29499194
Eur J Neurosci. 2013 Jul;38(1):2019-29
pubmed: 23651101
Nature. 2018 Nov;563(7729):72-78
pubmed: 30382198
Nature. 2019 Oct;574(7779):575-580
pubmed: 31645732
Elife. 2020 Jan 17;9:
pubmed: 31951199
J Proteome Res. 2017 Feb 3;16(2):599-608
pubmed: 28001079
Science. 2015 Sep 11;349(6253):1216-20
pubmed: 26359400
Am J Hum Genet. 2016 Oct 6;99(4):934-941
pubmed: 27616479
Curr Opin Neurobiol. 2014 Aug;27:75-81
pubmed: 24694749
Sci Rep. 2020 Oct 15;10(1):17445
pubmed: 33060836
Hum Mol Genet. 2020 Sep 30;29(R1):R27-R32
pubmed: 32644126
Elife. 2014 May 27;3:e02439
pubmed: 24867641
Am J Hum Genet. 2020 May 7;106(5):596-610
pubmed: 32243864
Biosci Rep. 2005 Oct-Dec;25(5-6):309-27
pubmed: 16307379
Dev Biol. 2014 Aug 15;392(2):233-44
pubmed: 24892953
Nature. 2011 Sep 21;478(7367):57-63
pubmed: 21937992
Hum Mol Genet. 2009 Jul 1;18(13):2483-94
pubmed: 19363039
Cell. 2010 Mar 5;140(5):678-91
pubmed: 20211137
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7287-E7296
pubmed: 27803317
J Med Genet. 2006 Mar;43(3):211-217
pubmed: 16169932
Genome Biol. 2013 Dec 31;14(12):R148
pubmed: 24380390
J Neurosci. 2003 Jan 1;23(1):203-12
pubmed: 12514217
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11472-7
pubmed: 9326634
J Hum Genet. 2018 Mar;63(3):349-356
pubmed: 29279609
PLoS Genet. 2017 Oct 25;13(10):e1006864
pubmed: 29069077
Am J Hum Genet. 2012 Jan 13;90(1):110-8
pubmed: 22177091
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4782-91
pubmed: 26261347
Nat Genet. 2017 Aug;49(8):1239-1250
pubmed: 28671686
Neuron. 2008 Feb 7;57(3):364-77
pubmed: 18255030
Mol Cell. 2008 Nov 21;32(4):503-18
pubmed: 19026781
Nature. 2012 Mar 28;484(7394):376-80
pubmed: 22456708
Mol Cell. 2003 Jun;11(6):1599-607
pubmed: 12820972
Am J Hum Genet. 2019 May 2;104(5):815-834
pubmed: 31031012
Nat Rev Neurosci. 2008 Jul;9(7):557-68
pubmed: 18568015
Am J Med Genet. 1990 Nov;37(3):304-10
pubmed: 2260555
Hum Mol Genet. 2013 Mar 1;22(5):852-66
pubmed: 23175442
Nat Rev Neurosci. 2015 Nov;16(11):647-59
pubmed: 26420377
Cell Physiol Biochem. 2018;47(6):2388-2395
pubmed: 29991052
Genome Res. 2015 Oct;25(10):1473-81
pubmed: 26430157
Am J Hum Genet. 2019 Apr 4;104(4):596-610
pubmed: 30879640
Mol Cell. 2010 Jan 15;37(1):46-56
pubmed: 20129054
Eur J Hum Genet. 2015 Jun;23(6):753-60
pubmed: 25138099
Science. 2020 Apr 10;368(6487):197-201
pubmed: 32273471
Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):290-301
pubmed: 25099957
Gene. 2017 Mar 20;605:92-98
pubmed: 27993705
Cell. 2020 Feb 6;180(3):568-584.e23
pubmed: 31981491
Mamm Genome. 2007 Feb;18(2):94-104
pubmed: 17334657
Nat Biotechnol. 2018 Jun;36(5):432-441
pubmed: 29658944
Clin Genet. 2012 Sep;82(3):248-55
pubmed: 21801163
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
pubmed: 18448678
Neuron. 2016 Sep 21;91(6):1219-1227
pubmed: 27657449
Behav Brain Res. 2010 Mar 17;208(1):47-55
pubmed: 19896504
Front Mol Neurosci. 2019 Oct 17;12:243
pubmed: 31680852
Biol Psychiatry. 2016 May 1;79(9):746-754
pubmed: 26185009
J Neurosci. 2002 Nov 15;22(22):9821-30
pubmed: 12427838
J Neurosci. 2017 Nov 8;37(45):10773-10782
pubmed: 29118205
Am J Hum Genet. 2012 Jun 8;90(6):1014-27
pubmed: 22633399
Nat Neurosci. 2009 Mar;12(3):311-7
pubmed: 19234456
Dev Neurobiol. 2014 May;74(5):483-97
pubmed: 24170322
Nucleic Acids Res. 2016 Jan 8;44(1):245-55
pubmed: 26609133
Cereb Cortex. 2019 Jun 1;29(6):2384-2395
pubmed: 29771284
Neuron. 2018 Dec 5;100(5):1180-1193.e6
pubmed: 30344048
J Neurosci. 2008 Nov 19;28(47):12570-80
pubmed: 19020049
Cell Rep. 2016 Mar 29;14(12):2797-808
pubmed: 26997278
Neurochem Int. 2000 Apr;36(4-5):291-300
pubmed: 10732996
Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11180-E11189
pubmed: 29229852
Neuron. 2016 Jul 20;91(2):260-92
pubmed: 27477017
J Neurosci. 2012 Jul 4;32(27):9429-37
pubmed: 22764251
Nat Commun. 2014 Jun 20;5:4181
pubmed: 24946904