Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.
Animals
Animals, Newborn
Cell Movement
Colony-Stimulating Factors
/ metabolism
Endothelial Cells
/ metabolism
Extracellular Matrix Proteins
/ metabolism
Integrin alphaVbeta3
/ metabolism
Lung
/ blood supply
Mice, Inbred C57BL
NF-kappa B
/ metabolism
Neovascularization, Physiologic
Nitric Oxide
/ biosynthesis
Premature Birth
Pulmonary Alveoli
/ metabolism
Sheep
Transforming Growth Factor beta
/ metabolism
alveolarization
bronchopulmonary dysplasia
colony-stimulating factor-3
endothelial migration
nitric oxide production
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
3
12
2020
medline:
26
3
2021
entrez:
2
12
2020
Statut:
ppublish
Résumé
Pulmonary angiogenesis is a key driver of alveolarization. Our prior studies showed that NF-κB promotes pulmonary angiogenesis during early alveolarization. However, the mechanisms regulating temporal-specific NF-κB activation in the pulmonary vasculature are unknown. To identify mechanisms that activate proangiogenic NF-κB signaling in the developing pulmonary vasculature, proteomic analysis of the lung secretome was performed using two-dimensional difference gel electrophoresis. NF-κB activation and angiogenic function was assessed in primary pulmonary endothelial cells (PECs) and TGFBI (transforming growth factor-β-induced protein)-regulated genes identified using RNA sequencing. Alveolarization and pulmonary angiogenesis was assessed in wild-type and
Identifiants
pubmed: 33264084
doi: 10.1165/rcmb.2020-0153OC
pmc: PMC7909333
doi:
Substances chimiques
Colony-Stimulating Factors
0
Extracellular Matrix Proteins
0
Integrin alphaVbeta3
0
NF-kappa B
0
Transforming Growth Factor beta
0
betaIG-H3 protein
148710-76-3
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-330Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL110002
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122918
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148165
Pays : United States
Commentaires et corrections
Type : CommentIn
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