Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics.
Acrospiroma
/ metabolism
Carcinoma, Adenoid Cystic
/ metabolism
Carcinoma, Basal Cell
/ metabolism
Carcinoma, Merkel Cell
/ metabolism
Carcinoma, Squamous Cell
/ metabolism
Humans
Immunohistochemistry
Sebaceous Gland Neoplasms
/ metabolism
Skin Neoplasms
/ metabolism
Sweat Gland Neoplasms
/ metabolism
Zinc Finger Protein GLI1
/ metabolism
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Sep 2021
01 Sep 2021
Historique:
pubmed:
3
12
2020
medline:
4
1
2022
entrez:
2
12
2020
Statut:
ppublish
Résumé
Basal cell carcinoma (BCC) is the most common skin cancer, and it has numerous histologic mimics with variable prognoses and treatments. Although some immunohistochemical stains can be used for the differential diagnosis of BCC, variability and overlap in results can complicate their interpretation. Immunohistochemical staining for glioma-associated oncogene-1 (Gli-1) was performed on 26 nodular BCCs, 22 infiltrative BCCs, 9 basaloid squamous cell carcinomas, 12 desmoplastic trichoepitheliomas, 19 Merkel cell carcinomas, 11 sebaceous carcinomas, 10 cylindromas, 14 spiradenomas, 12 adenoid cystic carcinomas (AdCC), and 1 solitary trichoepithelioma. Strength of staining was scored as 0, 1+, 2+, or 3+, and distribution of staining was categorized as diffuse, multifocal, or focal. Strong, diffuse Gli-1 expression was seen in all tumors with basal epidermal-type differentiation, including BCC, trichoepithelioma, and basaloid squamous cell carcinoma. All examples of Merkel cell carcinoma were negative for cytoplasmic expression. Seven out of 11 sebaceous carcinomas were negative for Gli-1, and the remaining 4 showed 1+ expression. Cylindroma, spiradenoma, and AdCC, each an adnexal skin tumor, showed the most variable staining, but with cylindroma and spiradenoma demonstrating comparable labeling patterns. Overall, although Gli-1 may not distinguish between basal epidermal-type tumors, it may have a role in separating that group from lesions with adnexal differentiation, particularly sebaceous carcinoma, but also cylindroma, spiradenoma, and AdCC. Any cytoplasmic staining seems to exclude the diagnosis of Merkel cell carcinoma.
Identifiants
pubmed: 33264133
pii: 00000372-202109000-00002
doi: 10.1097/DAD.0000000000001859
doi:
Substances chimiques
Zinc Finger Protein GLI1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-641Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Rogers HW, Weinstock MA, Feldman SR, et al. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012. JAMA Dermatol. 2015;151:1081–1086.
Stanoszek LM, Wang GY, Harms PW. Histologic mimics of basal cell carcinoma. Arch Pathol Lab Med. 2017;141:1490–1502.
Beer TW, Shepherd P, Theaker JM. Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin. Histopathology. 2000;37:218–223.
Gaballah MA, Ahmed RA. Diagnostic value of CD10 and Bcl2 expression in distinguishing cutaneous basal cell carcinoma from squamous cell carcinoma and seborrheic keratosis. Pathol Res Pract. 2015;211:931–938.
Mackiewicz-Wysocka M, Bowszyc-Dmochowska M, Strzelecka-Weklar D, et al. Basal cell carcinoma—diagnosis. Contemp Oncol. 2013;17:337–342.
Dahmane N, Lee J, Robins P, et al. Activation of the transcription factor Gli-1 and the sonic hedgehog signalling pathway in skin tumours. Nature. 1997;389:876–881.
Green J, Leigh IM, Poulsom R, et al. Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1. Br J Dermatol. 1998;139:911–915.
Nilsson M, Unden AB, Krause D, et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing Gli-1. Proc Natl Acad Sci. 2000;97:3438–3443.
Bigelow RL, Chari NS, Undén AB, et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through Gli-1. J Biol Chem. 2004;279:1197–1205.
Kim N, Kim JE, Choung HK, et al. Expression of Shh and Wnt signaling pathway proteins in eyelid sebaceous gland carcinoma: clinicopathologic study. Investig Ophthalmol Vis Sci. 2013;54:370–377.
Jeon SY, Kim DC, Song KH, et al. Expression patterns of Gli-1, pleckstrin homology-like domain, family A, member 1, transforming growth factor-β1/β2, and p63 in sebaceous and follicular tumors. Ann Dermatol. 2014;26:713–721.
Brunner M, Thurnher D, Pammer J, et al. Expression of hedgehog signaling molecules in Merkel cell carcinoma. Head Neck. 2010;32:333–340.
Cui D, Chen X, Yin J, et al. Aberrant activation of Hedgehog/Gli-1 pathway on angiogenesis in gliomas. Neurol India. 2012;60:589–596.