Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability.


Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
02 2021
Historique:
received: 21 05 2020
revised: 26 10 2020
accepted: 28 10 2020
pubmed: 3 12 2020
medline: 21 9 2021
entrez: 2 12 2020
Statut: ppublish

Résumé

As Alzheimer's disease (AD) pathology accumulates, resting-state functional connectivity (rs-fc) within and between brain networks decreases, and fluctuations in cognitive performance known as intraindividual variability (IIV) increase. Here, we assessed the relationship between IIV and anticorrelations in rs-fc between the default mode network (DMN)-dorsal attention network (DAN) in cognitively normal older adults and symptomatic AD participants. We also evaluated the relationship between cerebrospinal fluid (CSF) biomarkers of AD (amyloid-beta [Aβ

Identifiants

pubmed: 33264709
pii: S0197-4580(20)30339-0
doi: 10.1016/j.neurobiolaging.2020.10.027
pmc: PMC7903895
mid: NIHMS1668377
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0
Peptide Fragments 0
amyloid beta-protein (1-42) 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116-123

Subventions

Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG053474
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR012907
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB009352
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057680
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR012657
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052550
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AG000391
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR014449
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054567
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

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Auteurs

Karin L Meeker (KL)

Department of Psychology, Saint Louis University, St. Louis, MO, USA; Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: kmeeker@wustl.edu.

Beau M Ances (BM)

Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Brian A Gordon (BA)

Department of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Cort W Rudolph (CW)

Department of Psychology, Saint Louis University, St. Louis, MO, USA.

Patrick Luckett (P)

Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

David A Balota (DA)

Department of Psychology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

John C Morris (JC)

Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Anne M Fagan (AM)

Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Tammie L Benzinger (TL)

Department of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Jill D Waring (JD)

Department of Psychology, Saint Louis University, St. Louis, MO, USA.

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