Divergent effects of peripheral and global neuropeptide Y deletion.
Adipocyte
Cortical Bone
Mesenchymal Cells
Neuropeptide Y
Osteoblast
Journal
Journal of musculoskeletal & neuronal interactions
ISSN: 1108-7161
Titre abrégé: J Musculoskelet Neuronal Interact
Pays: Greece
ID NLM: 101084496
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
28
9
2021
Statut:
ppublish
Résumé
Neuropeptide Y (NPY) is involved in the coordination of bone mass and adiposity. However, multiple NPY sources exist and their individual contribution to the skeleton and adiposity not known. The objectives of our study were to evaluate the effects of peripheral mesenchymal derived NPY to the skeleton and adiposity and to compare them to the global NPY To study the role of mesenchymal-derived NPY, we crossed conditional NPY (NPY We identified the increase in cortical parameters in PrxNPY NPY mediates both positive and negative effects on bone mass via separate regulatory pathways. Deletion of mesenchymal-derived NPY had a positive effect on bone mass.
Substances chimiques
Neuropeptide Y
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-590Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR055607
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070813
Pays : United States
Déclaration de conflit d'intérêts
The authors have no conflict of interest.
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