Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, γ-Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells.

LPS Pseudomonas aeruginosa antioxidant cystic fibrosis glutathione oxidative stress redox

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
30 Nov 2020
Historique:
received: 12 10 2020
revised: 25 11 2020
accepted: 25 11 2020
entrez: 3 12 2020
pubmed: 4 12 2020
medline: 4 12 2020
Statut: epublish

Résumé

Systemic glutathione deficiency, inflammation, and oxidative stress are hallmarks of cystic fibrosis (CF), an inherited disease that causes persistent lung infections and severe damage to the respiratory system and many of the body organs. Improvements to current antioxidant therapeutic strategies are needed. The dietary supplement, γ-glutamylcysteine (GGC), which is the immediate precursor to glutathione, rapidly boosts cellular glutathione levels following a single dose in healthy individuals. Efficacy of GGC against oxidative stress induced by

Identifiants

DOI: 10.3390/antiox9121204 PMID: 33266084 PMC: PMC7760366
pubmed: 33266084
pii: antiox9121204
doi: 10.3390/antiox9121204
pmc: PMC7760366
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Chris K Hewson (CK)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, NSW 2052, Australia.
School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia.

Alexander Capraro (A)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, NSW 2052, Australia.
ORCID: 0000-0001-7596-8807

Sharon L Wong (SL)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, NSW 2052, Australia.

Elvis Pandzic (E)

Biomedical Imaging Facility, University of New South Wales, Sydney, NSW 2052, Australia.

Ling Zhong (L)

Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW 2052, Australia.

Bentotage S M Fernando (BSM)

School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
ORCID: 0000-0002-5613-5807

Nikhil T Awatade (NT)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, NSW 2052, Australia.

Gene Hart-Smith (G)

School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia.
Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia.

Renee M Whan (RM)

Biomedical Imaging Facility, University of New South Wales, Sydney, NSW 2052, Australia.

Shane R Thomas (SR)

School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.

Adam Jaffe (A)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, NSW 2052, Australia.
Department of Respiratory Medicine, Sydney Children's Hospital, Sydney, NSW 2031, Australia.

Wallace J Bridge (WJ)

School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia.

Shafagh A Waters (SA)

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, University of New South Wales and Sydney Children's Hospital, Sydney, NSW 2052, Australia.
Department of Respiratory Medicine, Sydney Children's Hospital, Sydney, NSW 2031, Australia.
ORCID: 0000-0003-1144-5411

Classifications MeSH