Seminal Plasma Proteomic Biomarkers of Oxidative Stress.
male infertility
oxidative stress
proteome
reactive oxygen species
seminal plasma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Nov 2020
30 Nov 2020
Historique:
received:
16
11
2020
revised:
28
11
2020
accepted:
28
11
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
6
3
2021
Statut:
epublish
Résumé
The prevalence of idiopathic male infertility is high, up to 75% of patients with abnormal sperm parameters. Hence, the research of its causes is mandatory. Oxidative stress (OS) can be responsible for male infertility in 30-80% of cases. In recent years, seminal plasma (SP) proteomics has developed as a useful tool to provide biomarkers of specific diseases. This systematic review aims to collect the available evidence on the changes of SP proteome in patients exposed to OS to provide possible SP biomarkers of sperm OS. To accomplish this, the following keyterms "seminal fluid proteome", "seminal plasma proteome", "oxidative stress", and "sperm oxidative stress" were used and 137 records were found. Among these, 17 were finally included. Nine proteins involved with OS were found overexpressed in patients with OS. Twenty-three proteins were found differentially expressed in patients with clinical conditions associated with OS, such as varicocele, male accessory gland infection/inflammation, cigarette smoke, and obesity. These proteins do not seem to overlap among the clinical conditions taken into account. We speculate that specific SP proteins may mediate OS in different clinical conditions. Altogether, these results suggest that proteomics could help to better understand some of the molecular mechanisms involved in the pathogenesis of infertility. However, further studies are needed to identify potential biomarkers of male infertility with valuable clinical significance.
Identifiants
pubmed: 33266209
pii: ijms21239113
doi: 10.3390/ijms21239113
pmc: PMC7731432
pii:
doi:
Substances chimiques
Biomarkers
0
Proteome
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Int J Mol Sci. 2019 Jan 08;20(1):
pubmed: 30626014
Clin Proteomics. 2015 Aug 28;12(1):23
pubmed: 26321892
Biomolecules. 2020 Jun 19;10(6):
pubmed: 32575588
Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):739-46
pubmed: 24067470
Sci Transl Med. 2013 Nov 20;5(212):212ra160
pubmed: 24259048
Fertil Steril. 2013 Aug;100(2):355-66.e2
pubmed: 23628110
Mol Med. 2007 Mar-Apr;13(3-4):199-202
pubmed: 17592555
Reprod Biomed Online. 2014 Jul;29(1):32-58
pubmed: 24813754
Hum Reprod Update. 2013 May-Jun;19(3):221-31
pubmed: 23242914
Int J Med Sci. 2020 Sep 20;17(17):2611-2621
pubmed: 33162789
J Assist Reprod Genet. 2014 May;31(5):549-54
pubmed: 24658925
Asian J Androl. 2009 Jul;11(4):484-91
pubmed: 19448646
J Proteomics. 2019 Mar 30;196:22-32
pubmed: 30710756
Int J Mol Sci. 2020 May 29;21(11):
pubmed: 32485940
Reprod Biomed Online. 2009 Oct;19(4):564-71
pubmed: 19909599
Andrology. 2016 May;4(3):447-55
pubmed: 27061999
Hum Reprod. 2012 Nov;27(11):3140-9
pubmed: 22863602
Med Genet. 2018;30(1):12-20
pubmed: 29527098
J Proteome Res. 2011 Mar 4;10(3):941-53
pubmed: 21142078
Andrologia. 2011 Apr;43(2):121-8
pubmed: 21382066
J Androl. 2012 Jan-Feb;33(1):53-8
pubmed: 21273503
Fertil Steril. 2013 Sep;100(3):667-72
pubmed: 23706337
Andrology. 2013 May;1(3):414-20
pubmed: 23427166
Redox Rep. 2012;17(5):227-32
pubmed: 22776017
Andrology. 2019 May;7(3):341-349
pubmed: 30891897
J Leukoc Biol. 2009 Sep;86(3):557-66
pubmed: 19451397
J Assist Reprod Genet. 2016 Dec;33(12):1657-1664
pubmed: 27629121
Int J Androl. 1993 Jun;16(3):183-8
pubmed: 8359932
Front Physiol. 2017 Mar 28;8:177
pubmed: 28400736
Urol Res. 2000 Dec;28(6):370-5
pubmed: 11221915
J Clin Med. 2019 Sep 08;8(9):
pubmed: 31500355
Protein Pept Lett. 2018;25(5):472-477
pubmed: 29651938
Hum Reprod. 2017 Jan;32(1):18-31
pubmed: 27864361
Int J Mol Sci. 2020 Oct 03;21(19):
pubmed: 33022946
J Androl. 2012 May-Jun;33(3):389-96
pubmed: 21636732
Dis Markers. 2015;2015:436236
pubmed: 25691806
Asian J Androl. 2019 Nov-Dec;21(6):544-550
pubmed: 31006709
Folia Histochem Cytobiol. 2007;45 Suppl 1:S123-6
pubmed: 18292819
World J Mens Health. 2019 May;37(2):148-156
pubmed: 30588778
Reprod Biol Endocrinol. 2015 Apr 26;13:37
pubmed: 25928197
Reproduction. 2017 Oct;154(4):R123-R131
pubmed: 28747541
Histol Histopathol. 2003 Apr;18(2):425-33
pubmed: 12647793
Urology. 1995 Jan;45(1):103-7
pubmed: 7817460
Clin Proteomics. 2012 Feb 06;9(1):2
pubmed: 22309592
BJU Int. 2016 Nov;118(5):814-822
pubmed: 27208688
Anal Bioanal Chem. 2016 Sep;408(23):6473-81
pubmed: 27422648
Indian J Biochem Biophys. 2010 Feb;47(1):38-43
pubmed: 21086753
Hum Reprod Update. 2016 Sep;22(5):574-87
pubmed: 27307387
Reprod Biol Endocrinol. 2013 Sep 03;11:85
pubmed: 24004880
Eur Urol. 1995;28(1):31-5
pubmed: 8521891
J Endocrinol Invest. 2011 Nov;34(10):e330-5
pubmed: 22234181
Andrologia. 1994 Sep-Oct;26(5):289-93
pubmed: 7825744
Andrologia. 2020 Jun;52(5):e13562
pubmed: 32150769
J Chemother. 2012 Apr;24(2):81-6
pubmed: 22546762
Fertil Steril. 2015 Aug;104(2):292-301
pubmed: 26048152
Fertil Steril. 1992 Feb;57(2):409-16
pubmed: 1735495
Reproduction. 2019 Jun;157(6):R209-R223
pubmed: 30780129
World J Mens Health. 2019 Mar 15;:
pubmed: 30929325
Hum Reprod. 2013 Jan;28(1):33-46
pubmed: 23042794
Electrophoresis. 1995 Jul;16(7):1090-4
pubmed: 7498152
Hum Reprod Update. 2008 May-Jun;14(3):243-58
pubmed: 18281241
Fertil Steril. 2013 Jan;99(1):92-98
pubmed: 23036805
J Clin Med. 2020 Jan 29;9(2):
pubmed: 32013061