The Role of Extracellular Vesicles in Demyelination of the Central Nervous System.
central nervous system
demyelination
extracellular vesicles
herpesviruses
multiple sclerosis
neuromyelitis optica
progressive multifocal leukoencephalopathy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Nov 2020
30 Nov 2020
Historique:
received:
02
11
2020
revised:
27
11
2020
accepted:
28
11
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
6
3
2021
Statut:
epublish
Résumé
It is being increasingly demonstrated that extracellular vesicles (EVs) are deeply involved in the physiology of the central nervous system (CNS). Processes such as synaptic activity, neuron-glia communication, myelination and immune response are modulated by EVs. Likewise, these vesicles may participate in many pathological processes, both as triggers of disease or, on the contrary, as mechanisms of repair. EVs play relevant roles in neurodegenerative disorders such as Alzheimer's or Parkinson's diseases, in viral infections of the CNS and in demyelinating pathologies such as multiple sclerosis (MS). This review describes the involvement of these membrane vesicles in major demyelinating diseases, including MS, neuromyelitis optica, progressive multifocal leukoencephalopathy and demyelination associated to herpesviruses.
Identifiants
pubmed: 33266211
pii: ijms21239111
doi: 10.3390/ijms21239111
pmc: PMC7729475
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : PID2019 110570GB-I00
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