MR Imaging Features to Differentiate Retinoblastoma from Coats' Disease and Persistent Fetal Vasculature.
Coats’ disease
MRI
persistent fetal vasculature
pseudoretinoblastoma
retinoblastoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Nov 2020
30 Nov 2020
Historique:
received:
19
10
2020
revised:
20
11
2020
accepted:
27
11
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
4
12
2020
Statut:
epublish
Résumé
Retinoblastoma mimickers, or pseudoretinoblastoma, are conditions that show similarities with the pediatric cancer retinoblastoma. However, false-positive retinoblastoma diagnosis can cause mistreatment, while false-negative diagnosis can cause life-threatening treatment delay. The purpose of this study is to identify the MR imaging features that best differentiate between retinoblastoma and the most common pseudoretinoblastoma diagnoses: Coats' disease and persistent fetal vasculature (PFV). Here, six expert radiologists performed retrospective assessments (blinded for diagnosis) of MR images of patients with a final diagnosis based on histopathology or clinical follow-up. Associations between 20 predefined imaging features and diagnosis were assessed with exact tests corrected for multiple hypothesis testing. Sixty-six patients were included, of which 33 (50%) were retinoblastoma and 33 (50%) pseudoretinoblastoma patients. A larger eye size, vitreous seeding, and sharp-V-shaped retinal detachment were almost exclusively found in retinoblastoma (
Identifiants
pubmed: 33266342
pii: cancers12123592
doi: 10.3390/cancers12123592
pmc: PMC7760210
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Stichting Kinderen Kankervrij
ID : 2018-342
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