Confirmation of five nitrofuran metabolites including nifursol metabolite in meat and aquaculture products by liquid chromatography-tandem mass spectrometry: Validation according to European Union Decision 2002/657/EC.
Liquid chromatography/mass spectrometry (LC-MS/MS)
Nifursol metabolite
Nitrofuran metabolites
Prohibited antimicrobials
Veterinary residues
Journal
Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639
Informations de publication
Date de publication:
16 Apr 2021
16 Apr 2021
Historique:
received:
25
05
2020
revised:
31
08
2020
accepted:
10
10
2020
pubmed:
4
12
2020
medline:
16
2
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
LC-MS/MS method for confirmation of nitrofuran metabolites in meat and aquaculture products, including the nifursol metabolite (DNSH), was developed. The nitrofuran metabolites investigated were as follows: 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), 1-aminohydantoine (AHD), semicarbazide (SEM) and 3,5-dinitrosalicylic acid hydrazide (DNSH). The sample preparation includes a washing step, allowing to analyze only the fraction of protein-bound residues. The final optimized recovery solvent for injection was found to be a mixture of ammonium acetate 2 mM/acetonitrile (60/40 ; v/v). Matrix effects and stability in biological matrix and standard solution for DNSH have been also carried out. Method performances were assessed using criteria of the Decision (EC) No 2002/657 and considering the proposed-for-adoption reference point for action (RPA) of 0.50 µg.kg
Identifiants
pubmed: 33268173
pii: S0308-8146(20)32251-2
doi: 10.1016/j.foodchem.2020.128389
pii:
doi:
Substances chimiques
Nitrofurans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
128389Informations de copyright
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